| Antisperm antibodies and human reproduction. | |
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MedLine Citation:
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PMID: 21077515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To present strategies in diagnosing and treating infertility related to antisperm antibodies. METHODS: Antisperm antibodies (ASA) were detected on sperm using the direct immunobead (IBD) test. Treatments included intrauterine insemination (IUI) with pretreatment with chymotrypsin/galactose vs. in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI). RESULTS: Intrauterine insemination with protein digestive enzyme treatment was much more effective than IUI without enzymatic therapy. However IVF with ICSI provided three times the pregnancy rate for males with sperm coated with ASA than IUI with chymotrypsin treated sperm. CONCLUSIONS: It is advisable to include measurement for ASA on the initial semen analysis. However, another option is to perform it initially only with an abnormal post-coital test. The decision for IUI with chymotrypsin pretreatment of the sperm vs. IVF with ICSI may depend on insurance and financial issues. |
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Authors:
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J H Check |
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Publication Detail:
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Type: Editorial |
Journal Detail:
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Title: Clinical and experimental obstetrics & gynecology Volume: 37 ISSN: 0390-6663 ISO Abbreviation: Clin Exp Obstet Gynecol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-16 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802110 Medline TA: Clin Exp Obstet Gynecol Country: Italy |
Other Details:
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Languages: eng Pagination: 169-74 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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analysis* Cervix Mucus / immunology Female Humans Immunoglobulin A / analysis Immunoglobulin G / analysis Infertility, Male / therapy* Insemination, Artificial Male Pregnancy Sperm Injections, Intracytoplasmic Spermatozoa / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Immunoglobulin A; 0/Immunoglobulin G |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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