| Antiseptics for preventing omphalitis. | |
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MedLine Citation:
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PMID: 12081124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Omphalitis may cause serious complications and contribute to neonatal morbidity and mortality. From January 1997 to August 1998, the incidence of omphalitis in the Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital had been increased from 0.9 to 17.4 per 1,000 live births. A prospective randomized trial using antiseptic applied directly to the umbilical stump was conducted aiming to reduce an epidemic outbreak of omphalitis in the newborn nursery. OBJECTIVE: To determine which antiseptic is appropriate for preventing omphalitis in the newborn infants. PATIENTS AND METHOD: Newborn infants delivered in the Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital were randomized into group A (Triple dye) or group B (70% Alcohol). The infant with omphalitis was assessed by a pediatrician or a neonatology fellow. At home, the same antiseptic will be continually applied to the umbilical stump daily until a few days after cord detachment. Relative risk was calculated and statistical significance was tested by Chi-square test. RESULTS: Four hundred and twenty-seven infants were enrolled. Birth weight, gestational age and gender of the infants in both groups were not different. There were no known maternal risk factors for omphalitis. Omphalitis was observed in 9/213 (4.2%) infants in group A and 23/214 (10.7%) infants in group B. The relative incidence rate between each group was statistically significant (p<0.01). Triple dye group was 60 per cent less likely to develop omphalitis compared to 70 per cent Alcohol group (RR 0.39, 95% CI: 0.19-0.83). The mean duration for cord detachment were 13.6 and 11.5 days in group A and group B, respectively. CONCLUSION: During an epidemic outbreak of omphalitis, Triple dye was the most appropriate and effective antiseptic to prevent omphalitis but could delay cord separation. |
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Authors:
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Sopapan Panyavudhikrai; Somwang Danchaivijitr; Chanchai Vantanasiri; Suwanna Trakulsomboon; Thrathip Kolatat; Chertsak Dhiraputra; Varaporn Poomsuwan; Nitaya Srihapol |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of the Medical Association of Thailand = Chotmaihet thangphaet Volume: 85 ISSN: 0125-2208 ISO Abbreviation: J Med Assoc Thai Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-06-25 Completed Date: 2002-07-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7507216 Medline TA: J Med Assoc Thai Country: Thailand |
Other Details:
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Languages: eng Pagination: 229-34 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents, Local
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administration & dosage* Bacterial Infections / epidemiology, microbiology, prevention & control* Chi-Square Distribution Female Humans Incidence Infant, Newborn Male Prospective Studies Thailand / epidemiology Treatment Outcome Umbilicus / microbiology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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