Document Detail

Antiseptal brain antibody in IgG of schizophrenic patients.
MedLine Citation:
PMID:  2923934     Owner:  NLM     Status:  MEDLINE    
On the hypothesis that schizophrenia is an immunological disorder in which antibody is produced against a unique antigen sequestered principally or exclusively in the septal region of the brain, we used crossed-immunoelectrophoresis (CIE) to evaluate reactivity of a gamma G immunoglobulin (IgG) fraction from serum of schizophrenic patients and nonschizophrenic control subjects with homogenates of tissues of septal region, hippocampus, vermal cerebellum, frontal cortex, and liver of rhesus monkeys. When IgG fractions of unmedicated schizophrenic patients and schizophrenic patients who had received neuroleptic medication for less than 24 hr were tested against septal region homogenate, a precipitin arc was identified, indicating a positive result, with more than 95% of the fractions. In contrast, IgG fractions of schizophrenic patients who had received neuroleptic medication for more than 24 hr were rarely positive. When schizophrenic fractions that tested positive against septal region homogenate were tested against homogenates of the other tissues, they were negative. Fractions of all nonschizophrenic control subjects were negative against all homogenates.
R G Heath; K L McCarron; C E O'Neil
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological psychiatry     Volume:  25     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-05-05     Completed Date:  1989-05-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  725-33     Citation Subset:  IM    
Department of Psychiatry, Tulane University School of Medicine, New Orleans, LA 70112.
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MeSH Terms
Autoantibodies / analysis*
Autoimmune Diseases / immunology
Blood Protein Electrophoresis
Delirium, Dementia, Amnestic, Cognitive Disorders / immunology*
Immunoglobulin G / analysis*
Schizophrenia / immunology*
Schizophrenic Psychology
Septum Pellucidum / immunology*
Reg. No./Substance:
0/Autoantibodies; 0/Immunoglobulin G
Comment In:
Biol Psychiatry. 1990 Mar 15;27(6):681-2   [PMID:  2322631 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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