| Antisense oligonucleotides to C-fos reduce postictal seizure susceptibility following fully kindled seizures in rats. | |
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MedLine Citation:
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PMID: 10406025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a previous study we demonstrated that increased FOS expression in the amygdala induced by partial kindling seizures could be attenuated by administering c-Fos specific antisense oligonucleotides. In addition, we found that the administration of c-Fos antisense oligonucleotides at the beginning of the amygdala kindling process facilitated the appearance of stage V kindled seizures. In the present study, we evaluated the effect of the suppression of FOS on the expression and severity of the generalized fully kindled seizures as well as on the susceptibility to additional ictal events during the postictal and interictal periods. We observed that the administration of c-Fos antisense oligonucleotides did not modify the behavioral and electrographic manifestations of generalized stage V kindled seizures. However, c-Fos antisense oligonucleotides significantly reduced the susceptibility to additional ictal events during the postictal refractory period. Hence, the increased FOS protein induced by generalized tonic clonic seizures may participate in postictal mechanisms. |
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Authors:
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L Rocha; R Ondarza; D L Kaufman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroscience letters Volume: 268 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-09-01 Completed Date: 1999-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 143-6 Citation Subset: IM |
Affiliation:
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Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico, Mexico. rocha@ssa.gob.mx |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amygdala
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metabolism Animals Kindling, Neurologic* / genetics Male Oligonucleotides, Antisense / therapeutic use* Proto-Oncogene Proteins c-fos / antagonists & inhibitors*, metabolism Rats Rats, Wistar Seizures / drug therapy*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Oligonucleotides, Antisense; 0/Proto-Oncogene Proteins c-fos |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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