Document Detail


Antisense oligonucleotides fail to inhibit the expression of central beta adrenergic receptors.
MedLine Citation:
PMID:  9055346     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A number of antisense phosphorothioate oligodeoxynucleotides (ODNs) targeted to different regions of mRNAs were tested for their ability to inhibit the expression of central beta adrenergic receptors (ARs). None of these antisense ODNs reduced beta AR density. By contrast, a dopamine D2 receptor antisense ODN did decrease striatal D2 receptor density. The recovery of beta AR density after down-regulation was not altered by any of the antisense ODNs tested. Moreover, the response of rats under a DRL 72-sec schedule to clenbuterol, a beta-2 selective AR agonist, was not attenuated by chronic treatment with a beta-2 AR antisense ODN.
Authors:
K Zhang; J M O'Donnell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Research communications in molecular pathology and pharmacology     Volume:  95     ISSN:  1078-0297     ISO Abbreviation:  Res. Commun. Mol. Pathol. Pharmacol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-06-23     Completed Date:  1997-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9437512     Medline TA:  Res Commun Mol Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  21-32     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Therapeutics, Louisiana State University School of Medicine, Shreveport 71130, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / pharmacology
Adrenergic beta-Antagonists / administration & dosage,  pharmacology*
Animals
Brain / drug effects,  metabolism
Clenbuterol / pharmacology
Injections, Intraventricular
Male
Oligonucleotides, Antisense / administration & dosage,  pharmacology*
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic, beta / genetics,  metabolism
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Adrenergic beta-Antagonists; 0/Oligonucleotides, Antisense; 0/Receptors, Adrenergic, beta; 37148-27-9/Clenbuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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