Document Detail

Antisense oligonucleotides fail to inhibit the expression of central beta adrenergic receptors.
MedLine Citation:
PMID:  9055346     Owner:  NLM     Status:  MEDLINE    
A number of antisense phosphorothioate oligodeoxynucleotides (ODNs) targeted to different regions of mRNAs were tested for their ability to inhibit the expression of central beta adrenergic receptors (ARs). None of these antisense ODNs reduced beta AR density. By contrast, a dopamine D2 receptor antisense ODN did decrease striatal D2 receptor density. The recovery of beta AR density after down-regulation was not altered by any of the antisense ODNs tested. Moreover, the response of rats under a DRL 72-sec schedule to clenbuterol, a beta-2 selective AR agonist, was not attenuated by chronic treatment with a beta-2 AR antisense ODN.
K Zhang; J M O'Donnell
Related Documents :
1652646 - Adriamycin-induced changes to the myocardial beta-adrenergic system in the rabbit.
9931136 - Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrop...
7667366 - The inhibition of sexual behavior in male rats by propranolol is stereoselective.
8847266 - Altered beta-adrenergic and cholinergic pulmonary vascular responses after total cardio...
22553026 - Subunit-selective allosteric inhibition of glycine binding to nmda receptors.
20434496 - Swallow-related inhibition in laryngeal motoneurons.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Research communications in molecular pathology and pharmacology     Volume:  95     ISSN:  1078-0297     ISO Abbreviation:  Res. Commun. Mol. Pathol. Pharmacol.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-06-23     Completed Date:  1997-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9437512     Medline TA:  Res Commun Mol Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  21-32     Citation Subset:  IM    
Department of Pharmacology and Therapeutics, Louisiana State University School of Medicine, Shreveport 71130, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenergic beta-Agonists / pharmacology
Adrenergic beta-Antagonists / administration & dosage,  pharmacology*
Brain / drug effects,  metabolism
Clenbuterol / pharmacology
Injections, Intraventricular
Oligonucleotides, Antisense / administration & dosage,  pharmacology*
Rats, Sprague-Dawley
Receptors, Adrenergic, beta / genetics,  metabolism
Tumor Cells, Cultured
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Adrenergic beta-Antagonists; 0/Oligonucleotides, Antisense; 0/Receptors, Adrenergic, beta; 37148-27-9/Clenbuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Ubiquinol/ubiquinone ratio as marker of oxidative stress in coronary artery disease.
Next Document:  Desmethyl tirilazad reduces brain nitric oxide synthase activity and cyclic guanosine monophosphate ...