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Antisense Technologies Targeting Fatty Acid Synthetic Enzymes.
MedLine Citation:
PMID:  22339357     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Fatty acid synthesis is a coordinated process involving multiple enzymes. Overexpression of some of these enzymes plays important roles in tumor growth and development. Therefore, these enzymes are attractive targets for cancer therapies. Antisense agents provide highly specific inhibition of the expression of target genes and thus have served as powerful tools for gene functional studies and potential therapeutic agents for cancers. This article reviews different types of antisense agents and their applications in the modulation of fatty acid synthesis. Patents of antisense agents targeting fatty acid synthetic enzymes are introduced. In addition, miR-122 has been shown to regulate the expression of fatty acid synthetic enzymes, and thus antisense agent patents that inhibit miR-122 expression are also discussed.
Authors:
Jinshun Lin; Feng Liu; Yuyang Jiang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-20
Journal Detail:
Title:  Recent patents on anti-cancer drug discovery     Volume:  -     ISSN:  2212-3970     ISO Abbreviation:  Recent Pat Anticancer Drug Discov     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101266081     Medline TA:  Recent Pat Anticancer Drug Discov     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Guangdong Provincial Key Laboratory of Chemical Biology, Tsinghua University Graduate School at Shenzhen, Shenzhen, 518055, P.R. China. jiangyy@sz.tsinghua.edu.cn.
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