Document Detail


Antisense Oligonucleotide Targeting Matrix Metalloproteinase-7 (MMP-7) Changes the Ultrastructure of Human A549 Lung Adenocarcinoma Cells.
MedLine Citation:
PMID:  21981819     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Antisense oligonucleotide (ASODN) targeting specific gene can be capable of potently downregulating proliferation and invasion in human cancer cells. However, the underlying mechanisms are less well defined. Here the authors show that matrix metalloproteinase-7 (MMP-7) ASODN changes the ultrastructure of human A549 lung adenocarcinoma cells. Transfection of MMP-7 ASODN significantly lowered the expression of MMP-7 protein in A549 cells. Decreased microvilli, endoplasmic reticulum dilation, swelling of mitochondria, and formation of apoptotic bodies were observed by transmission electron microscope. Collectively, the findings identified the morphological mechanism that MMP-7 ASODN inhibited proliferation and invasion in A549 cells.
Authors:
Bo Yang; Jianfei Gao; Zhiguo Rao; Bicheng Zhang; Wen Ouyang; Chunxu Yang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-7
Journal Detail:
Title:  Ultrastructural pathology     Volume:  -     ISSN:  1521-0758     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8002867     Medline TA:  Ultrastruct Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Oncology, Wuhan General Hospital of Guangzhou Command PLA , Wuhan, P.R. China.
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