Document Detail

Antisecretory factor-inducing therapy improves the clinical outcome in patients with M?ni?re's disease.
MedLine Citation:
PMID:  19479454     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: Intake of antisecretory factor (AF)-inducing SPC-flakes significantly reduced vertigo in patients suffering from M?ni?re's disease (MD). The positive effect may be due to a modulation of the transport of water and ions in the endolymphatic space. OBJECTIVE: To evaluate the effects of a 3-month treatment period with SPC-flakes in patients suffering from MD. PATIENTS AND METHODS: A prospective, double-blind, placebo-controlled study was performed. A total of 51 adult patients with MD were included in the study: 27 subjects treated with SPC-flakes and 24 subjects with control cereals. The patients received SPC-flakes or control cereals (1 g per kg body weight per 24 h in two servings) for 3 months. Otoneurological examinations were carried out before and after this period. RESULTS: The severity of MD was classified according to the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) grading system. Fourteen of the 27 patients randomized to intake of the AF-inducing SPC-flakes reported decreased vertigo, compared with 2 of 24 in the control group (p < 0.001). No consistent change in the otoneurological examinations could be demonstrated in any of the groups of patients.
Per Hanner; Helge Rask-Andersen; Stefan Lange; Eva Jennische
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  130     ISSN:  1651-2251     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-03-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  England    
Other Details:
Languages:  eng     Pagination:  223-7     Citation Subset:  IM    
Department of Audiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
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MeSH Terms
Aged, 80 and over
Cochlea / metabolism,  physiopathology
Double-Blind Method
Endolymphatic Sac / metabolism,  physiopathology
Meniere Disease / diet therapy*,  metabolism,  physiopathology
Middle Aged
Neuropeptides / metabolism*
Prospective Studies
Vertigo / metabolism,  physiopathology,  therapy
Reg. No./Substance:
0/Neuropeptides; 0/antisecretory factor

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