| Antisecretory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene antagonism, on gastric acid secretion in the pig. | |
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MedLine Citation:
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PMID: 8079817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antisecretory effect of DS-4574, a mast cell stabilizer with peptidoleukotriene antagonism, on the hypersecretion of gastric acid stimulated by several secretagogues was examined in the pig. Goettingen miniature pigs with chronic gastric fistula were used. Intramuscular injection of carbachol (60 micrograms/kg), tetragastrin (50 micrograms/kg) or histamine (200 micrograms/kg)-induced gastric acid hypersecretion. Intraduodenal administration of DS-4574 (10 and 20 mg/kg) significantly inhibited both the hypersecretion induced by carbachol and that by tetragastrin. On the other hand, DS-4574 (50 mg/kg, intraduodenal) did not suppress histamine-induced hypersecretion. In the in vitro study, no effect on hog gastric K(+)-dependent ATPase activity was found at concentrations of DS-4574 from 10(-7) to 10(-4) M. These results were highly similar to those in the rat. The suppression of histamine release from histamine-containing cells in the gastric mucosa of the rat was concluded to be an antisecretory effect of DS-4574. |
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Authors:
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Y Yamashika; Y Tabuchi; E Kokue |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Agents and actions Volume: 41 ISSN: 0065-4299 ISO Abbreviation: Agents Actions Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-10-03 Completed Date: 1994-10-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0213341 Medline TA: Agents Actions Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 17-20 Citation Subset: IM |
Affiliation:
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Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphatases
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metabolism* Animals Carbachol / pharmacology Cation Transport Proteins Female Gastric Acid / secretion* Gastric Mucosa / drug effects*, enzymology, secretion Histamine / pharmacology Injections, Intramuscular Leukotriene Antagonists* Male Pyrimidines / pharmacology*, therapeutic use Swine Swine, Miniature Tetragastrin / pharmacology Triazoles / pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Cation Transport Proteins; 0/Leukotriene Antagonists; 0/Pyrimidines; 0/Triazoles; 118314-35-5/DS 4574; 1947-37-1/Tetragastrin; 51-45-6/Histamine; 51-83-2/Carbachol; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/potassium transporting ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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