Document Detail


Antisecretory, antioxidative and antiapoptotic effects of montelukast on pyloric ligation and water immersion stress induced peptic ulcer in rat.
MedLine Citation:
PMID:  20153621     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, we tried to explore the mechanism of montelukast as an antiulcerogenic agent in pyloric ligation (PL) and water immersion stress (WIS) induced peptic ulcer. The ameliorative effects of montelukast (5, 10, and 20 mg/kg, p.o.) on gastric volume and total acidity were studied in PL model. We have investigated the alteration in the ulcerative index, thiobarbituric acid reactive substances, reduced glutathione, activity of myeloperoxidase, and total calcium level in both models. Estimation of DNA fragmentation by gel electrophoresis was also performed. Medium and higher doses of montelukast showed significant (p<0.05) ameliorative potential on all the above parameters as compared with omeprazole treated group. DNA fragmentation pattern clearly indicated the antiapoptotic effect of montelukast in preventing mucosal erosion in both models. Hence, the gastroprotective effect of montelukast may be attributed to its antisecretory, antioxidative along with its antiapoptotic effect.
Authors:
Arunachalam Muthuraman; Shailja Sood
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-12
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  83     ISSN:  1532-2823     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Rayat Institute of Pharmacy, Nawanshahr District, Railmajra, Near Ropar, Punjab 144533, India. aruachalammu@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Acetates / pharmacology*
Animals
DNA Fragmentation / drug effects
Disease Models, Animal
Glutathione / blood
Leukotriene Antagonists / pharmacology*
Male
Peptic Ulcer / blood*,  drug therapy*,  etiology,  pathology
Peroxidase / blood
Quinolines / pharmacology*
Rats
Rats, Wistar
Stomach / metabolism,  pathology
Stress, Psychological / blood*,  complications,  drug therapy*,  pathology
Thiobarbituric Acid Reactive Substances / analysis
Chemical
Reg. No./Substance:
0/Acetates; 0/Leukotriene Antagonists; 0/Quinolines; 0/Thiobarbituric Acid Reactive Substances; 158966-92-8/montelukast; 70-18-8/Glutathione; EC 1.11.1.7/Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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