Document Detail


Antisecretory activity of plants used to treat gastrointestinal disorders in Mexico.
MedLine Citation:
PMID:  16174555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aqueous and methanolic extracts from 26 medicinal plants used in Mexico to treat gastrointestinal disorders were screened to evaluate their antisecretory activity on cholera toxin-induced intestinal secretion in rat jejunal loops model. Extracts were tested at a dose of 300 mg/kg. From 56 samples tested, both extracts from Chiranthodendron pentadactylon, Hippocratea excelsa and Ocimum basilicum were the most potent with inhibition values ranging from 68.0 to 87.6%. On the other hand, the methanolic extract of Geranium mexicanum (aerial parts) and the aqueous extract of Bocconia frutescens showed the highest activity with inhibition values of 93.4 and 86.0%, respectively. The results obtained in this study give some scientific support to the use of the Mexican medicinal plants employed for the treatment of gastrointestinal disorders such as diarrhea.
Authors:
Claudia Velázquez; Fernando Calzada; Javier Torres; Felipe González; Guillermo Ceballos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-09-19
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  103     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-11-28     Completed Date:  2006-03-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  66-70     Citation Subset:  IM    
Affiliation:
Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatría, 2 degrees Piso, Centro Médico Nacional Siglo XXI, IMSS, Col. Doctores, CP 06725, México DF. fercalber1@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholera Toxin / pharmacology
Gastrointestinal Diseases / drug therapy*
Intestinal Mucosa / drug effects*,  secretion
Male
Mexico
Phytotherapy*
Plant Extracts / pharmacology*
Plants, Medicinal*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Plant Extracts; 9012-63-9/Cholera Toxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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