| Antisecretory activity of plants used to treat gastrointestinal disorders in Mexico. | |
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MedLine Citation:
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PMID: 16174555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aqueous and methanolic extracts from 26 medicinal plants used in Mexico to treat gastrointestinal disorders were screened to evaluate their antisecretory activity on cholera toxin-induced intestinal secretion in rat jejunal loops model. Extracts were tested at a dose of 300 mg/kg. From 56 samples tested, both extracts from Chiranthodendron pentadactylon, Hippocratea excelsa and Ocimum basilicum were the most potent with inhibition values ranging from 68.0 to 87.6%. On the other hand, the methanolic extract of Geranium mexicanum (aerial parts) and the aqueous extract of Bocconia frutescens showed the highest activity with inhibition values of 93.4 and 86.0%, respectively. The results obtained in this study give some scientific support to the use of the Mexican medicinal plants employed for the treatment of gastrointestinal disorders such as diarrhea. |
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Authors:
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Claudia Velázquez; Fernando Calzada; Javier Torres; Felipe González; Guillermo Ceballos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-09-19 |
Journal Detail:
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Title: Journal of ethnopharmacology Volume: 103 ISSN: 0378-8741 ISO Abbreviation: J Ethnopharmacol Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-11-28 Completed Date: 2006-03-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
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Languages: eng Pagination: 66-70 Citation Subset: IM |
Affiliation:
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Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatría, 2 degrees Piso, Centro Médico Nacional Siglo XXI, IMSS, Col. Doctores, CP 06725, México DF. fercalber1@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholera Toxin / pharmacology Gastrointestinal Diseases / drug therapy* Intestinal Mucosa / drug effects*, secretion Male Mexico Phytotherapy* Plant Extracts / pharmacology* Plants, Medicinal* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts; 9012-63-9/Cholera Toxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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