Document Detail

Antisecretory activity of omeprazole in the conscious gastric fistula cat: comparison with famotidine.
MedLine Citation:
PMID:  2531863     Owner:  NLM     Status:  MEDLINE    
The antisecretory activity of the H+/K+ ATPase inhibitor omeprazole was studied in the conscious gastric fistula cat in comparison with the H2-blocker famotidine. Omeprazole caused a dose-dependent inhibition of the dimaprit-induced acid secretion, being approximately fivefold less potent than famotidine (intravenous ID50S were 0.34 +/- 0.03 and 0.067 +/- 0.015 mumol/kg for omeprazole and famotidine, respectively). Omeprazole caused a non-competitive inhibition of the dose-response curve to dimaprit, whereas famotidine induced a parallel shift to the right without depressing the maximum response. Conversely from famotidine, the antisecretory effect of omeprazole was found to be dependent on the acid secretory state of the stomach, the effect being more evident when the compound was administered at the plateau of acid secretion. The inhibitory effect of omeprazole was very long lasting (25% inhibition was still present 24 h after administration of the drug) whereas that of famotidine was overcome by dimaprit infusion within 3-4 h. The antisecretory effect of omeprazole concerned to the same extent the volume and the acid concentration of the gastric juice, whereas famotidine reduced mainly the volume. When the stimulus was represented by pentagastrin the intravenous ID50 values were 0.57 +/- 0.03 and 0.088 +/- 0.015 mumol/kg for omeprazole and famotidine. respectively. From the above data it may be concluded that the antisecretory profile of omeprazole differed markedly from that of famotidine, independently from the potency and the efficacy of the two drugs.
G Coruzzi; G Bertaccini
Related Documents :
1551523 - Regulation of gastric acid secretion by gastrin in duodenal ulcer patients and healthy ...
2563963 - Pancreatic enzyme replacement therapy. importance of gastric acid secretion, h2-antagon...
6644743 - Antibacterially active substituted anilides of carboxylic and sulfonic acids.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  21     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:    1989 Sep-Oct
Date Detail:
Created Date:  1990-01-25     Completed Date:  1990-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  499-506     Citation Subset:  IM    
Institute of Pharmacology, University of Parma, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Ulcer Agents / pharmacology*
Dose-Response Relationship, Drug
Famotidine / pharmacology*
Gastric Acid / secretion
Gastric Fistula / metabolism*
Injections, Intravenous
Omeprazole / pharmacology*
Pentagastrin / pharmacology
Thiourea / diagnostic use
Reg. No./Substance:
0/Anti-Ulcer Agents; 5534-95-2/Pentagastrin; 62-56-6/Thiourea; 65119-89-3/Dimaprit; 73590-58-6/Omeprazole; 76824-35-6/Famotidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Reversible obstructive hypertrophic cardiomyopathy in the Beckwith-Wiedemann syndrome.
Next Document:  Anorexia nervosa and Down syndrome