Document Detail


Antischistosomal activity of aminoalkanethiols, aminoalkanethiosulfuric acids and the corresponding disulfides.
MedLine Citation:
PMID:  18996349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper discusses the development of a series of sulfur-containing compounds that show an interesting in vivo activity against infection by Schistosoma mansoni. These substances include the aminoalkanethiols, aminoalkanethiosulfuric acids and aminoalkyl disulfides, among others. Although the aminoethanethiols and their disulfide derivatives have presented a relatively high toxicity for the host animal, the aminoalkanethiosulfuric acids have a low toxicity and a high specificity for the adult female S. mansoni worms. In vitro studies with schistosomula, lung-phase schistosomula and adult worms have demonstrated effects on the tegument and the metabolism on these different stages of S. mansoni worms. The encapsulation of these drugs in a nanoemulsion has resulted in an increase in the in vitro activity.
Authors:
Marcus Luiz de Oliveira Penido; Paulo Marcos Zech Coelho; Rômulo Teixeira de Mello; Dorila Piló-Veloso; Mônica Cristina de Oliveira; John Robert Kusel; David Lee Nelson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-10-22
Journal Detail:
Title:  Acta tropica     Volume:  108     ISSN:  1873-6254     ISO Abbreviation:  Acta Trop.     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-12-02     Completed Date:  2009-01-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370374     Medline TA:  Acta Trop     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  249-55     Citation Subset:  IM    
Affiliation:
Departamento de Bioquímica-Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais e Instituto Medicina Legal, Belo Horizonte, MG, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antiprotozoal Agents / chemistry,  pharmacology,  therapeutic use*,  toxicity*
Female
Humans
Mice
Schistosoma mansoni / drug effects*
Schistosomiasis mansoni / drug therapy*
Sulfur Compounds / chemistry,  pharmacology,  therapeutic use*,  toxicity*
Chemical
Reg. No./Substance:
0/Antiprotozoal Agents; 0/Sulfur Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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