| Antiretroviral use during pregnancy for treatment or prophylaxis. | |
| | |
MedLine Citation:
|
PMID: 21534886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Antiretrovirals are recommended for all pregnant women either for treatment of HIV-1 infection or for prevention of mother-to-child transmission. Distinguishing between HIV-1-infected pregnant women who meet treatment criteria and those who do not (who use antiretrovirals during pregnancy for prophylaxis) is accomplished by assessing the HIV-1 disease stage and has important implications regarding when antiretroviral drugs are initiated during pregnancy, what drugs are used and antiretroviral use after delivery. AREAS COVERED: This review addresses antiretroviral use by HIV-1-infected women during pregnancy. Specifically, the review focuses on antiretroviral therapy for HIV-1-infected pregnant women who meet criteria for treatment and antiretroviral prophylaxis for HIV-1-infected pregnant women (to prevent mother-to-child transmission of HIV-1). The review primarily addresses antiretroviral use in resource-rich settings, but use in resource-poor settings is briefly addressed. EXPERT OPINION: Antiretrovirals represent only one component of the overall management of HIV-1 infected pregnant women and, therefore, cannot be viewed in isolation from other components of optimal care for HIV-1-infected women and from other efficacious interventions to prevent mother-to-child transmission of HIV-1. Antiretrovirals can be used safely and effectively during pregnancy. We concur with current guidelines regarding the threshold that differentiates which women need antiretroviral therapy for HIV-1 infection for their own health versus those who need prophylaxis to prevent transmission of HIV-1 infection to their child. We thus recommend that lifelong antiretroviral therapy be initiated in patients with an AIDS-defining illness, a CD4 count < 350 cells/mm(3) or other co-morbid conditions such as acute opportunistic infections, HIV-1-associated nephropathy or hepatitis B co-infection. Irrespective of whether or not antiretrovirals are used during pregnancy, or whether antiretrovirals during pregnancy are used for treatment or prophylaxis, all infants of HIV-1-infected women should receive antiretroviral post-exposure prophylaxis. |
| | |
Authors:
|
Amy S Sturt; Jennifer S Read |
Related Documents
:
|
2620966 - Leucocyte and serum ascorbic acid levels in mothers and their newborn in semi-arid west... 21385426 - Nutritional status of iodine in pregnant women in catalonia (spain): study on hygiene-d... 6108256 - Malarial immunity in pregnant nigerian women and their newborn. 7294886 - Cadmium and lead content of maternal and newborn hair: relationship to parity, birth we... 18461816 - Generalized blind delayed source separation model for online non-invasive twin-fetal so... 6275566 - Prenatal diagnosis of sickle cell anemia and beta-thalassemia by amniocentesis. |
Publication Detail:
|
Type: Journal Article; Review Date: 2011-05-03 |
Journal Detail:
|
Title: Expert opinion on pharmacotherapy Volume: 12 ISSN: 1744-7666 ISO Abbreviation: Expert Opin Pharmacother Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-07-18 Completed Date: 2011-11-28 Revised Date: 2013-05-20 |
Medline Journal Info:
|
Nlm Unique ID: 100897346 Medline TA: Expert Opin Pharmacother Country: England |
Other Details:
|
Languages: eng Pagination: 1875-85 Citation Subset: IM |
Affiliation:
|
Medicine/Infectious Diseases, Santa Clara Valley Medical Center, Ira Greene PACE Clinic, 751 S. Bascom Avenue, San Jose, CA 95128 , USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Animals Anti-HIV Agents / adverse effects, therapeutic use Anti-Retroviral Agents / adverse effects, therapeutic use* Drug Monitoring Female HIV Infections / drug therapy*, therapy, transmission* HIV-1* Humans Infant, Newborn Infant, Newborn, Diseases / prevention & control Infectious Disease Transmission, Vertical / prevention & control* Male Medication Adherence Post-Exposure Prophylaxis Practice Guidelines as Topic Pregnancy Pregnancy Complications, Infectious / drug therapy*, therapy Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Anti-HIV Agents; 0/Anti-Retroviral Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sitagliptin or exenatide once weekly for type 2 diabetes: comparison of the clinical trials.
Next Document: Medical treatment of glaucoma: present and future.