Document Detail

Antiretroviral treatment in pregnancy.
MedLine Citation:
PMID:  19372959     Owner:  NLM     Status:  In-Data-Review    
PURPOSE OF REVIEW: With combination antiretroviral therapy, perinatal HIV transmission can be decreased to less than 1%. With this remarkable success, in areas with adequate resources, attention has now been turned to the safety of these medications for the mother and the fetus. This review will discuss relevant publications, from the past year, regarding safety and pharmacokinetics, particularly pertaining to the resource-rich setting.
RECENT FINDINGS: Studies are in disagreement about an association between antiretrovirals and prematurity and other adverse pregnancy outcomes. The pharmacokinetics of some antiretroviral medications are altered significantly during pregnancy, while others appear unchanged. Placental transfer to the fetus is variable. Reports about mitochondrial toxicity in the infant provide conflicting conclusions. Potential toxicities in both the mother and fetus are areas of concern.
SUMMARY: While the well documented benefit in preventing mother-to-child transmission generally outweighs the potential risks to the fetus, infant and mother, there are legitimate concerns. Clinicians providing care to HIV-infected pregnant women must have a thorough understanding of these potential complications. More data on the safety and pharmacokinetics of antiretrovirals during pregnancy are needed.
Alice Marie Stek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in HIV and AIDS     Volume:  3     ISSN:  1746-6318     ISO Abbreviation:  Curr Opin HIV AIDS     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2009-04-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264945     Medline TA:  Curr Opin HIV AIDS     Country:  United States    
Other Details:
Languages:  eng     Pagination:  155-60     Citation Subset:  -    
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Southern California School of Medicine, Los Angeles, California, USA.
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