Document Detail


Antiretroviral treatment 2010: progress and controversies.
MedLine Citation:
PMID:  21045599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effective antiretroviral therapy (ART) changes the clinical course of HIV infection. There are 25 antiretroviral drugs approved for the treatment of HIV infection, and current antiretroviral drug regimens are highly effective, convenient, and relatively nontoxic. ART regimens should be chosen in consideration of a patient's particular clinical situation. Successful treatment is associated with durable suppression of HIV viremia over years, and consequently, ART reduces the risk of clinical progression. In fact, current models estimate that an HIV-infected individual appropriately treated with antiretroviral drugs has a life expectancy that approaches that of the general HIV-uninfected population, although some patient groups such as injection drug users do less well. Despite these advances, continued questions about ART persist: What is the optimal time to start ART? What is the best regimen to start? When is the optimal time to change ART? What is the best regimen to change to? In addition, newer antiretroviral agents are in development, both in existing classes and in new classes such as the CD4 receptor attachment inhibitors and the maturation inhibitors. Further research will help optimize current antiretroviral treatments and strategies.
Authors:
Roy M Gulick
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  55 Suppl 1     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-03     Completed Date:  2010-11-22     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S43-8     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Anti-HIV Agents / administration & dosage,  therapeutic use*
Drug Administration Schedule
HIV Infections / drug therapy*
Humans
Grant Support
ID/Acronym/Agency:
AI-51966/AI/NIAID NIH HHS; K24 AI051966/AI/NIAID NIH HHS; K24 AI051966-07/AI/NIAID NIH HHS; K24 AI051966-08/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-HIV Agents
Comments/Corrections

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