| Antiretroviral-treated HIV-infected women have similar long-term kidney function trajectories as HIV-uninfected women. | |
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MedLine Citation:
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PMID: 23273313 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Natural history studies suggest increased risk for kidney function decline with HIV, but few studies have made comparisons with HIV-uninfected women. We examined whether HIV treated with highly active antiretroviral therapy (HAART) remains associated with faster kidney function decline in the Women's Interagency HIV Study. Methods: HIV-infected women initiating HAART with (N=105) or without (N=373) tenofovir (TDF) were matched to HIV-uninfected women on calendar and length of follow-up, age, systolic blood pressure, hepatitis C antibody serostatus and diabetes history. Linear mixed models were used to evaluate differences in annual estimated glomerular filtration rate (eGFR). Results: Person-visits were 4,741 and 11,512 for the TDF-treated and nonTDF-treated analyses, respectively. Mean baseline eGFRs were higher among women initiated on TDF-containing HAART and lower among those on TDF-sparing HAART compared to their respective HIV-uninfected matches (P<0.05 for both). HIV-infected women had similar annual rates of eGFR changes as HIV-uninfected matches (P-interaction >0.05 for both). Adjusting for baseline eGFR, mean eGFRs at 1 and 3 years of follow-up among women initiated on TDF-containing HAART were lower than their uninfected matches (-4.98 and -4.26 mL/min|1.73 m2, respectively; P<0.05 for both). Mean eGFR of women initiated on TDF-sparing HAART was lower versus uninfected matches at 5 years (-2.19 mL/min|1.73 m2, P=0.03). Conclusions: HAART-treated HIV-infected women had lower mean eGFRs at follow-up but experienced similar rates of annual eGFR decline as HIV-uninfected women. Tenofovir use in HIV-infected women with normal kidney function did not accelerate long-term kidney function decline relative to HIV-uninfected women. |
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Authors:
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Michelle M Estrella; Alison Gump Abraham; Yuezhou Jing; Rulan Parekh; Phyllis C Tien; Daniel Merenstein; Celeste L Pearce; Kathryn Anastos; Mardge Cohen; Jack Dehovitz; Stephen Gange |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-30 |
Journal Detail:
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Title: AIDS research and human retroviruses Volume: - ISSN: 1931-8405 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Johns Hopkins School of Medicine, Division of Nephrology, 1830 E. Monument St., Suite 415, Baltimore, Maryland, United States, 21205; mestrel1@jhmi.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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