Document Detail


Antiretroviral-treated HIV-infected women have similar long-term kidney function trajectories as HIV-uninfected women.
MedLine Citation:
PMID:  23273313     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Natural history studies suggest increased risk for kidney function decline with HIV infection, but few studies have made comparisons with HIV-uninfected women. We examined whether HIV infection treated with highly active antiretroviral therapy (HAART) remains associated with faster kidney function decline in the Women's Interagency HIV Study. HIV-infected women initiating HAART with (n=105) or without (n=373) tenofovir (TDF) were matched to HIV-uninfected women on calendar and length of follow-up, age, systolic blood pressure, hepatitis C antibody serostatus, and diabetes history. Linear mixed models were used to evaluate differences in annual estimated glomerular filtration rate (eGFR). Person-visits were 4,741 and 11,512 for the TDF-treated and non-TDF-treated analyses, respectively. Mean baseline eGFRs were higher among women initiated on TDF-containing HAART and lower among those on TDF-sparing HAART compared to their respective HIV-uninfected matches (p<0.05 for both). HIV-infected women had annual rates of eGFR changes similar to HIV-uninfected matches (p-interaction >0.05 for both). Adjusting for baseline eGFR, mean eGFRs at 1 and 3 years of follow-up among women initiated on TDF-containing HAART were lower than their uninfected matches (-4.98 and -4.26 ml/min/1.73 m(2), respectively; p<0.05 for both). Mean eGFR of women initiated on TDF-sparing HAART was lower versus uninfected matches at 5 years (-2.19 ml/min/1.73 m(2), p=0.03). HAART-treated HIV-infected women had lower mean eGFRs at follow-up but experienced rates of annual eGFR decline similar to HIV-uninfected women. Tenofovir use in HIV-infected women with normal kidney function did not accelerate long-term kidney function decline relative to HIV-uninfected women.
Authors:
Michelle M Estrella; Alison G Abraham; Yuezhou Jing; Rulan S Parekh; Phyllis C Tien; Dan Merenstein; Celeste Leigh Pearce; Kathryn Anastos; Mardge H Cohen; Jack A Dehovitz; Stephen J Gange
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2013-01-29
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  29     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-26     Completed Date:  2013-08-30     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  755-60     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiretroviral Therapy, Highly Active*
Creatinine / blood
Female
Glomerular Filtration Rate
HIV Infections / complications*,  drug therapy
Humans
Prospective Studies
Renal Insufficiency / etiology*
Grant Support
ID/Acronym/Agency:
K23 DK081317/DK/NIDDK NIH HHS; K23DK081317/DK/NIDDK NIH HHS; U01 AI031834/AI/NIAID NIH HHS; U01 AI034994/AI/NIAID NIH HHS; U01 AI035004/AI/NIAID NIH HHS; UL1 RR024131/RR/NCRR NIH HHS; UL1 TR000101/TR/NCATS NIH HHS; UO1-AI-31834/AI/NIAID NIH HHS; UO1-AI-34989/AI/NIAID NIH HHS; UO1-AI-34993/AI/NIAID NIH HHS; UO1-AI-34994/AI/NIAID NIH HHS; UO1-AI-35004/AI/NIAID NIH HHS; UO1-AI-42590/AI/NIAID NIH HHS; UO1-HD-32632/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
AYI8EX34EU/Creatinine
Comments/Corrections

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