Document Detail

Antiretroviral therapy may improve sensory function in HIV-infected patients: a pilot study.
MedLine Citation:
PMID:  10851375     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate thermal and nociceptive function in a prospective, longitudinal study of 49 consecutive HIV-1-infected patients before and at 1, 4, and 8 months after initiation of highly active antiretroviral therapy. METHODS: Quantitative assessments of thermal perception thresholds for warmth (dWT), cold (dCT), and heat pain (HPT) were performed. CD4+ cell levels in blood and HIV-1 RNA levels in plasma were determined. Depending on the virologic response to treatment, the patients were divided into two groups: responders (37 of 49, 76%) and nonresponders (12 of 49, 24%). RESULTS: Before treatment, impairment of dWT was found in 26 of 49 patients, of dCT in 33 of 49 patients, and of HPT in 19 of 49 patients. Improvements of perception thresholds for dWT (p < 0.0001), dCT (p < 0.001), and HPT (p < 0.01) were observed after 8 months of treatment in the responder group but not in the nonresponders. Within the responder group, improved thermal perception thresholds was associated with higher pretreatment CD4+ levels than in patients without improvement. CONCLUSIONS: Virologically successful antiretroviral combination therapy of HIV-1-infected patients has a capacity to improve function of the thermal and nociceptive systems, especially in patients with less advanced immunodeficiency.
C Martin; G Solders; A Sönnerborg; P Hansson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  54     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-07-13     Completed Date:  2000-07-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2120-7     Citation Subset:  AIM; IM; X    
Department of Neurology, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Analysis of Variance
Anti-HIV Agents / pharmacology,  therapeutic use*
Chi-Square Distribution
HIV Infections / complications,  drug therapy*
Middle Aged
Pilot Projects
Prospective Studies
RNA, Viral / metabolism
Sensation Disorders / drug therapy*,  etiology
Temperature Sense / drug effects*
Reg. No./Substance:
0/Anti-HIV Agents; 0/RNA, Viral
Comment In:
Neurology. 2000 Jun 13;54(11):2037-8   [PMID:  10851359 ]

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