| [Antiretroviral prophylaxis after non-occupational exposure to HIV in Abidjan (Cote d'Ivoire)]. | |
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MedLine Citation:
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PMID: 20554137 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to assess the tolerability and adherence to all non-occupational post-exposure prophylaxis (PEP) for cases of HIV exposure in Abidjan. METHOD: We retrospectively studied all post-exposure prophylaxis for non-occupational exposures to HIV prescribed from January 1st, 2000 to December 31st, 2007 in the Abidjan infectious diseases department. We analyzed the types of exposure, socio-demographic characteristics of patients, antiretroviral therapy regimens, adherence and tolerability, duration of the treatment, and post-exposure follow-up. RESULTS: Over these eight years, we managed 128 consultations for non-professional exposures to HIV (50 male [39%], 78 female patients [61%]), average age 24.8 years (four-54 years). The most frequent exposures were due to rape (n=74), condom rupture (n=29), and occasional unprotected sex (n=21). The average delay before consultation was 20.8 hours. The antiretroviral chemoprophylaxis included a protease inhibitor in 93% of the cases; 80.5% of patients completed 28 days of chemoprophylaxis, while 8.6% interrupted the treatment, and 10.9% were lost to follow-up. The most frequent adverse effects were gastrointestinal, reported by 79 patients (61.7%). Only 34 patients (26.6%) returned for clinical and biological post-exposure follow-up with HIV control at third month, without documented seroconversion. CONCLUSION: Cases of sexual exposure to HIV are the main indication for post-exposure prophylaxis in Abidjan, except for occupational exposure to blood. However, post-exposure prophylaxis should be available in the units of primary care, such as emergencies departments. |
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Authors:
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E Ehui; A Tanon; P Guié; T Aba; C Toa-Lou; A Kassi; I Ouattara; G Kouakou; C Mossou; A Kakou; S Eholié; E Aoussi; E Bissagnéné |
Publication Detail:
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Type: English Abstract; Journal Article |
Journal Detail:
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Title: Médecine et maladies infectieuses Volume: 40 ISSN: 1769-6690 ISO Abbreviation: Med Mal Infect Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0311416 Medline TA: Med Mal Infect Country: France |
Other Details:
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Languages: fre Pagination: 574-81 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Service des maladies infectieuses et tropicales, CHU de Treichville, 01 BP V 3, Abidjan 01, Cote-d'Ivoire. docehui@yahoo.fr |
Vernacular Title:
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Prophylaxie antirétrovirale après expositions non professionnelles au VIH à Abidjan (Cote d'Ivoire). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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