| Antiretroviral agents and acid-base balance at delivery of the neonate. | |
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MedLine Citation:
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PMID: 17653449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Limited evidence is available regarding antiretroviral (ARV) safety for uninfected infants exposed to these drugs in utero. Our objective was to determine if ARV administered to pregnant women is associated with decreasing umbilical arterial pH and base excess in uninfected infants. A prospective study was conducted on 57 neonates divided into three groups: ZDV group, born to mothers taking zidovudine (N = 20), triple therapy (TT) group, born to mothers taking zidovudine + lamivudine + nelfinavir (N = 25), and control group (N = 12), born to uninfected mothers. Umbilical cord blood was used to determine umbilical artery gases. A test was performed to calculate the sample by comparing means by the unpaired one-tailed t-test, with alpha = 0.05 and beta = 20%, indicating the need for a sample of 18 newborn infants for the study groups to detect differences higher than 20%. The control and ARV groups were similar in gestational age, birth weight, and Apgar scores. Values of pH, pCO2, bicarbonate, and base excess in cord arterial blood obtained at delivery from the newborns exposed to TT were 7.23, 43.2 mmHg, 19.5 mEq/L, and -8.5 nmol/L, respectively, with no significant difference compared to the control and ZDV groups. We conclude that intrauterine exposure to ARV is not associated with a pathological decrease in umbilical arterial pH or base excess. While our data are reassuring, follow-up is still limited and needs to be continued into adulthood because of the possible potential for adverse effects of triple antiretroviral agents. |
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Authors:
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P El-Beitune; G Duarte; E N de Morais; O Campbell; P Spara-Gadelha; F Mauad-Filho; S M Quintana; L C Rodrigues |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 40 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-26 Completed Date: 2008-04-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: Brazil |
Other Details:
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Languages: eng Pagination: 957-61 Citation Subset: IM |
Affiliation:
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Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil. pbeitune@yahoo.com.br |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium
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drug effects* Adult Anti-HIV Agents / adverse effects, therapeutic use* Case-Control Studies Drug Therapy, Combination Female Fetal Blood / chemistry* HIV Infections / blood, drug therapy* Humans Hydrogen-Ion Concentration / drug effects Infant, Newborn Infectious Disease Transmission, Vertical / prevention & control Lamivudine / adverse effects, therapeutic use Nelfinavir / adverse effects, therapeutic use Pregnancy Pregnancy Outcome Prospective Studies Zidovudine / adverse effects, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 134678-17-4/Lamivudine; 159989-64-7/Nelfinavir; 30516-87-1/Zidovudine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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