Document Detail

Antiretroviral Preexposure Prophylaxis for HIV Prevention.
MedLine Citation:
PMID:  23281985     Owner:  NLM     Status:  In-Data-Review    
To the Editor: Thigpen et al. (Aug. 2 issue)(1) report that persons who are seronegative for the human immunodeficiency virus (HIV) and who are receiving tenofovir disoproxil fumarate and emtricitabine (TDF-FTC) for preexposure prophylaxis had decreased bone mineral density at 24 months, as compared with those receiving placebo. In HIV-infected cohorts, TDF causes an initial loss of bone density over a period of 6 to 12 months, but there is stable bone density subsequently.(2),(3) These findings are consistent with other studies that have shown short-term loss of bone density in patients initiating antiretroviral treatment but stable bone density in . . .
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The New England journal of medicine     Volume:  368     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  82-4     Citation Subset:  AIM; IM    
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