Document Detail


Antipyrine disposition in relation to lowered anticonvulsant plasma level during pregnancy.
MedLine Citation:
PMID:  6815599     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The authors studied antipyrine disposition before and after delivery in 4 epileptic women whose anticonvulsant plasma level per dosage ratio was lowered during pregnancy, and compared the results to those found in nonpregnant women undergoing antiepileptic treatment (N = 6) and healthy women (N = 6). The antipyrine clearance at term (0.53 +/- 0.11 ml/min/kg, mean +/- SD) was lower than it was early during puerperium (0.70 +/- 0.14 ml/min/kg, P less than .05) and approximately 3 months after delivery (1.14 +/- 0.26 ml/min/kg, P less than .01). The antipyrine clearance in nonpregnant epileptics (1.17 +/- 0.44 ml/min/kg) was comparable to that found 3 months after delivery, whereas it was significantly (P less than .01) higher than that found in healthy women (0.47 +/- 0.02 ml/min/kg). These observations suggest that the fall during pregnancy of anticonvulsant plasma concentrations relative to dosage is not attributable to the enhanced oxidative process of hepatic drug metabolism.
Authors:
K Chiba; T Ishizaki; T Tabuchi; T Wagatsuma; Y Nakazawa
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  60     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1982 Nov 
Date Detail:
Created Date:  1983-01-07     Completed Date:  1983-01-07     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  620-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticonvulsants / blood*
Antipyrine / metabolism*
Delivery, Obstetric
Dose-Response Relationship, Drug
Epilepsy / drug therapy*,  metabolism
Female
Half-Life
Humans
Infant, Newborn
Metabolic Clearance Rate
Phenobarbital / blood
Phenytoin / blood
Postpartum Period
Pregnancy
Pregnancy Complications / metabolism*
Time Factors
Valproic Acid / blood
Chemical
Reg. No./Substance:
0/Anticonvulsants; 50-06-6/Phenobarbital; 57-41-0/Phenytoin; 60-80-0/Antipyrine; 99-66-1/Valproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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