| Antipyretic effect of acetaminophen suppositories in rats. | |
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MedLine Citation:
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PMID: 315458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An animal model used yeast-fevered rats to measure the relative antipyretic effects of different commercially available acetaminophen-containing suppositories. A laboratory-prepared acetaminophen-containing suppository and placebo suppositories also were investigated. Release from the suppositories was measured in vitro. All acetaminophen products containing 600 mg of drug elicited significant decreases in the rectal temperature of fever-induced rats. |
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Authors:
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A Lock; B M Eckman; J Ayres |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 68 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1979 Sep |
Date Detail:
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Created Date: 1980-01-19 Completed Date: 1980-01-19 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1105-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetaminophen
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administration & dosage,
pharmacology* Animals Anti-Inflammatory Agents, Non-Steroidal* Fever / chemically induced Male Rats Rectum Suppositories Time Factors Yeasts |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Suppositories; 103-90-2/Acetaminophen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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