Document Detail


Antipsychotic medication during pregnancy and lactation in women with schizophrenia: evaluating the risk.
MedLine Citation:
PMID:  12553132     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To review studies investigating the following: whether exposing developing infants to antipsychotic medication during pregnancy and lactation is associated with increased risks of teratogenic, neonatal, and long-term neurobehavioural sequelae; whether schizophrenia itself affects pregnancy outcome; and whether the course of schizophrenia symptoms is altered by pregnancy and lactation. METHOD: We summarize the results from articles identified via a MedLine search for the period January 1, 1966, to December 1, 2001. RESULTS: Women with schizophrenia are at increased risk for poor obstetrical outcomes, including preterm delivery, low birth weight, and neonates who are small for their gestational age. A lack of information in the literature makes it difficult to comment on the relative risk of exposing developing infants to atypical antipsychotics. However, typical antipsychotics appear to carry an increased risk of congenital malformations when the fetus is exposed to phenothiazines during weeks 4 to 10 of gestation. Lack of information also precludes an understanding of whether changes associated with pregnancy and lactation significantly alter the course of schizophrenia symptoms. CONCLUSION: Research is needed so that physicians may more accurately inform women about the relative risks of using antipsychotic medications during pregnancy and lactation. Increased knowledge about the risks of medication exposure will allow clinicians to limit treatment to situations in which the risk of untreated maternal illness outweighs the risk of exposing a developing infant to medications.
Authors:
Sheila W Patton; Shaila Misri; Maria R Corral; Katherine F Perry; Annie J Kuan
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Canadian journal of psychiatry. Revue canadienne de psychiatrie     Volume:  47     ISSN:  0706-7437     ISO Abbreviation:  Can J Psychiatry     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2003-01-29     Completed Date:  2003-02-26     Revised Date:  2007-08-01    
Medline Journal Info:
Nlm Unique ID:  7904187     Medline TA:  Can J Psychiatry     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  959-65     Citation Subset:  IM    
Affiliation:
University of British Columbia, Vancouver, British Columbia. spatton@cw.bc.ca
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / chemically induced
Antipsychotic Agents / adverse effects*
Female
Fetal Diseases / chemically induced
Humans
Infant, Newborn
Lactation / drug effects
Phenothiazines / adverse effects*
Postpartum Period
Pregnancy
Pregnancy Complications
Pregnancy Outcome
Prenatal Exposure Delayed Effects
Schizophrenia / drug therapy*
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 0/Phenothiazines
Comments/Corrections
Comment In:
Evid Based Ment Health. 2003 Aug;6(3):89   [PMID:  12893800 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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