| Antipsychotic medication during pregnancy and lactation in women with schizophrenia: evaluating the risk. | |
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MedLine Citation:
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PMID: 12553132 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To review studies investigating the following: whether exposing developing infants to antipsychotic medication during pregnancy and lactation is associated with increased risks of teratogenic, neonatal, and long-term neurobehavioural sequelae; whether schizophrenia itself affects pregnancy outcome; and whether the course of schizophrenia symptoms is altered by pregnancy and lactation. METHOD: We summarize the results from articles identified via a MedLine search for the period January 1, 1966, to December 1, 2001. RESULTS: Women with schizophrenia are at increased risk for poor obstetrical outcomes, including preterm delivery, low birth weight, and neonates who are small for their gestational age. A lack of information in the literature makes it difficult to comment on the relative risk of exposing developing infants to atypical antipsychotics. However, typical antipsychotics appear to carry an increased risk of congenital malformations when the fetus is exposed to phenothiazines during weeks 4 to 10 of gestation. Lack of information also precludes an understanding of whether changes associated with pregnancy and lactation significantly alter the course of schizophrenia symptoms. CONCLUSION: Research is needed so that physicians may more accurately inform women about the relative risks of using antipsychotic medications during pregnancy and lactation. Increased knowledge about the risks of medication exposure will allow clinicians to limit treatment to situations in which the risk of untreated maternal illness outweighs the risk of exposing a developing infant to medications. |
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Authors:
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Sheila W Patton; Shaila Misri; Maria R Corral; Katherine F Perry; Annie J Kuan |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Canadian journal of psychiatry. Revue canadienne de psychiatrie Volume: 47 ISSN: 0706-7437 ISO Abbreviation: Can J Psychiatry Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2003-01-29 Completed Date: 2003-02-26 Revised Date: 2007-08-01 |
Medline Journal Info:
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Nlm Unique ID: 7904187 Medline TA: Can J Psychiatry Country: Canada |
Other Details:
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Languages: eng Pagination: 959-65 Citation Subset: IM |
Affiliation:
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University of British Columbia, Vancouver, British Columbia. spatton@cw.bc.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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chemically induced Antipsychotic Agents / adverse effects* Female Fetal Diseases / chemically induced Humans Infant, Newborn Lactation / drug effects Phenothiazines / adverse effects* Postpartum Period Pregnancy Pregnancy Complications Pregnancy Outcome Prenatal Exposure Delayed Effects Schizophrenia / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Phenothiazines |
| Comments/Corrections | |
Comment In:
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Evid Based Ment Health. 2003 Aug;6(3):89
[PMID:
12893800
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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