Document Detail

Antipsychotic-induced life-threatening 'esophageal dyskinesia'.
MedLine Citation:
PMID:  10220128     Owner:  NLM     Status:  MEDLINE    
We report two patients with lingual dyskinesia and complaints of food regurgitation following long-term antipsychotic therapy. Esophageal contrast radiography revealed dyskinetic movements extending from the pharynx to the upper portion of the esophagus. The elevation of intraesophageal pressure was confirmed by esophageal manometry. The dyskinetic movements almost disappeared along with improvement of lingual dyskinesia following the administration of sulpiride in one patient. Another patient suddenly died due to asphyxiation of foods before the beginning of treatment. We termed this life-threatening movement, 'esophageal dyskinesia'. It should be emphasized that 'esophageal dyskinesia' associated with lingual dyskinesia is a potentially fatal adverse reaction to antipsychotic therapy.
J Horiguchi; T Shingu; T Hayashi; A Kagaya; S Yamawaki; Y Horikawa; Y Kitadai; M Inoue; T Nishikawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International clinical psychopharmacology     Volume:  14     ISSN:  0268-1315     ISO Abbreviation:  Int Clin Psychopharmacol     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-01     Completed Date:  1999-06-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8609061     Medline TA:  Int Clin Psychopharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  123-7     Citation Subset:  IM    
Department of Psychiatry and Neurosciences, Hiroshima University School of Medicine, Hiroshima City, Japan.
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MeSH Terms
Antipsychotic Agents / adverse effects*
Dyskinesia, Drug-Induced / etiology*,  physiopathology
Esophagus / physiopathology*
Reg. No./Substance:
0/Antipsychotic Agents

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