Document Detail

Antipsychotic treatment patterns and aggressive behavior among adolescents in residential facilities.
MedLine Citation:
PMID:  23319375     Owner:  NLM     Status:  MEDLINE    
This study examined the association between acute aggressive behavior patterns of 145 adolescents in residential treatment facilities with use of and changes in antipsychotic medication for the chronic management of aggression. Seclusion/restraint (S/R) frequency over 12 months was used to categorize youth into none, low, moderate, and high S/R groups. Data were analyzed using longitudinal mixed effects logistic regression models that allowed for intra-subject variability over time. The high and moderate S/R groups were significantly more likely to receive antipsychotics, get higher doses, and have changes in medication compared with the none S/R group. Increases in antipsychotic dose were associated with a lower likelihood of changes in antipsychotic medication over time. Despite persistent antipsychotic use at higher doses, youth in the high and moderate S/R groups continued to be secluded/restrained frequently. The findings question the adequacy of these medications in managing aggressive behavior.
Leslie Miller; Mark A Riddle; David Pruitt; Al Zachik; Susan dosReis
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of behavioral health services & research     Volume:  40     ISSN:  1556-3308     ISO Abbreviation:  J Behav Health Serv Res     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-02-08     Completed Date:  2013-06-18     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  9803531     Medline TA:  J Behav Health Serv Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  97-110     Citation Subset:  IM    
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MeSH Terms
Aggression / drug effects*
Antipsychotic Agents / therapeutic use*
Dose-Response Relationship, Drug
Drug Administration Schedule
Length of Stay
Logistic Models
Residential Facilities
Residential Treatment / methods,  statistics & numerical data*
Restraint, Physical / statistics & numerical data*
Retrospective Studies
Severity of Illness Index
Socioeconomic Factors
Treatment Outcome
Grant Support
T32 MH020033/MH/NIMH NIH HHS; T32 MH20033-10/MH/NIMH NIH HHS
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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