Document Detail

Antiprotozoal activity of the constituents of Teloxys graveolens.
MedLine Citation:
PMID:  12916068     Owner:  NLM     Status:  MEDLINE    
Antiprotozoal activity-guided fractionation of a methanol extract of the aerial parts of Teloxys graveolens led to the isolation of one coumarinic acid derivative, melilotoside, and five flavonoids, pinocembrine, pinostrobin, chrysin, narcissin and rutin. Among them, melilotoside exhibited the most potent activity toward Entamoeba histolytica and Giardia lamblia (IC(50) 12.5 and 16.8 micro g/mL, respectively). Narcissin showed selectivity against E. histolytlica (IC(50) 17.2 micro g/mL). The results support data for the traditional use of T. graveolens in some gastrointestinal diseases.
Fernando Calzada; Claudia Velázquez; Roberto Cedillo-Rivera; Baldomero Esquivel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  17     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-13     Completed Date:  2003-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  731-2     Citation Subset:  IM    
Copyright Information:
Copyright 2003 John Wiley & Sons, Ltd.
Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatría, 2 piso, Centro Médico Nacional Siglo XXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores, CP 06725, México, D. F.
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MeSH Terms
Antiprotozoal Agents / administration & dosage,  pharmacology*,  therapeutic use
Entamoeba histolytica / drug effects
Entamoebiasis / drug therapy
Giardia lamblia / drug effects
Giardiasis / drug therapy
Inhibitory Concentration 50
Parasitic Sensitivity Tests
Plant Components, Aerial
Plant Extracts / administration & dosage,  pharmacology*,  therapeutic use
Reg. No./Substance:
0/Antiprotozoal Agents; 0/Plant Extracts

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