| Antiprotozoal activity of the constituents of Teloxys graveolens. | |
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MedLine Citation:
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PMID: 12916068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antiprotozoal activity-guided fractionation of a methanol extract of the aerial parts of Teloxys graveolens led to the isolation of one coumarinic acid derivative, melilotoside, and five flavonoids, pinocembrine, pinostrobin, chrysin, narcissin and rutin. Among them, melilotoside exhibited the most potent activity toward Entamoeba histolytica and Giardia lamblia (IC(50) 12.5 and 16.8 micro g/mL, respectively). Narcissin showed selectivity against E. histolytlica (IC(50) 17.2 micro g/mL). The results support data for the traditional use of T. graveolens in some gastrointestinal diseases. |
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Authors:
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Fernando Calzada; Claudia Velázquez; Roberto Cedillo-Rivera; Baldomero Esquivel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 17 ISSN: 0951-418X ISO Abbreviation: Phytother Res Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-08-13 Completed Date: 2003-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 731-2 Citation Subset: IM |
Copyright Information:
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Copyright 2003 John Wiley & Sons, Ltd. |
Affiliation:
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Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatría, 2 piso, Centro Médico Nacional Siglo XXI, IMSS, Av. Cuauhtémoc 330, Col. Doctores, CP 06725, México, D. F. fercalberl@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amaranthaceae* Animals Antiprotozoal Agents / administration & dosage, pharmacology*, therapeutic use Entamoeba histolytica / drug effects Entamoebiasis / drug therapy Giardia lamblia / drug effects Giardiasis / drug therapy Inhibitory Concentration 50 Parasitic Sensitivity Tests Phytotherapy* Plant Components, Aerial Plant Extracts / administration & dosage, pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antiprotozoal Agents; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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