Document Detail


Antiproliferative properties of flavone acetic acid (NSC 347512) (LM 975), a new anticancer agent.
MedLine Citation:
PMID:  3678316     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antiproliferative activity of flavone acetic acid (LM 975) was investigated on human adenocarcinoma cell lines (HCC-P2998, HCC-M1544, HCC-M1410, HT 29, LoVo), on a murine colon adenocarcinoma cell line (Colon 26), on murine pancreatic adenocarcinoma cells growing in primary culture (Pan 03) and on human normal fibroblasts (N1). No cytotoxic effects were found against human normal fibroblasts. LM 975 was active against murine adenocarcinoma Pan 03 and Colon 26, known to be sensitive in vivo too and, to variable extents, on human adenocarcinoma cell lines. LM 975 in vitro cytotoxic potency was relatively low. The high concentrations (1.0-1.4 mM) required to obtain a cytotoxic effect are, however, pharmacologically reasonable since they are comparable with drug plasma levels in mice or in patients treated with tolerable doses. After a relatively short LM 975 treatment (2 h) DNA, RNA and protein synthesis were inhibited in different proportions. In more sensitive cells LM 975 appeared to inhibit RNA synthesis more than DNA and protein synthesis. Inhibition of macromolecule synthesis after 2 h exposure was completely reversed in 24 h recovery. After 2 h treatment no detectable DNA breakage was found by the alkaline elution method, thus corroborating the idea that this compound does not act by causing DNA damage.
Authors:
L S Capolongo; G Balconi; P Ubezio; R Giavazzi; G Taraboletti; A Regonesi; O C Yoder; M D'Incalci
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cancer & clinical oncology     Volume:  23     ISSN:  0277-5379     ISO Abbreviation:  Eur J Cancer Clin Oncol     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-01-12     Completed Date:  1988-01-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8112045     Medline TA:  Eur J Cancer Clin Oncol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1529-35     Citation Subset:  IM    
Affiliation:
Istituto di Richerche Farmacologiche, Mario Negri, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / metabolism,  pathology
Animals
Antineoplastic Agents / pharmacology*
Cell Division / drug effects
Cell Line
DNA Damage
DNA, Neoplasm / biosynthesis
Fibroblasts / drug effects
Flavonoids / pharmacology*
Humans
Mice
Neoplasm Proteins / biosynthesis
Neoplastic Stem Cells / drug effects
RNA, Neoplasm / biosynthesis
Tumor Cells, Cultured / drug effects*,  metabolism
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/DNA, Neoplasm; 0/Flavonoids; 0/Neoplasm Proteins; 0/RNA, Neoplasm; 87626-55-9/flavone acetic acid

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