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Antiproliferative and genotoxic effects of Mikania glomerata (Asteraceae).
MedLine Citation:
PMID:  21443139     Owner:  NLM     Status:  In-Process    
Mikania glomerata is a plant used in Brazilian traditional medicine, known as 'guaco'. It possesses anti-inflammatory properties and the aqueous extracts of its leaves are indicated for the treatment of diseases of the respiratory tract. This study aimed at evaluating the antiproliferative and genotoxic effect of Mikania glomerata leaf infusions on the cell cycle of onion. The material used was collected in the native environment from Rio Grande do Sul State, Brazil. Aqueous extracts through infusions were prepared in two concentrations: 4g/L (usual concentration) and 16g/L (4x more concentrated) of each of the populations. Two groups of four onion bulbs for each plant population were used plus a control group. The rootlets were fixed in ethanol-acetic acid (3:1), conserved in ethanol 70% and slides were prepared using the squashing technique colored with orcein 2%. The cells were observed and analyzed during cell cycle. Per group of bulbs, 2000 cells were analyzed, and the mean values of the cell number of each of the phases of the cell cycle were calculated, determining the mitotic index (MI). Statistic analyses of the data were carried out by the x2 ( p= 0.05) test. We conclude that M. glomerata presents both antiproliferative and genotoxic activity.
Gracieli Dalla Nora; Tamara Pastori; Haywood Dail Laughinghouse; Thais Scotti Do Canto-Dorow; Solange Bosio Tedesco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biocell : official journal of the Sociedades Latinoamericanas de Microscopía Electronica ... et. al     Volume:  34     ISSN:  0327-9545     ISO Abbreviation:  Biocell     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-03-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9438655     Medline TA:  Biocell     Country:  Argentina    
Other Details:
Languages:  eng     Pagination:  95-101     Citation Subset:  IM    
Department of Biology, Universidade Federal de Santa Maria, UFSM, Santa Maria, RS, Brazil.
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