Document Detail


Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cells.
MedLine Citation:
PMID:  19048608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The chemical constituents and antiproliferative effects on SW480 human colorectal cancer cells of different plant parts of P. notoginseng were evaluated. The contents of saponins in extracts from root, rhizome, flower and berry of P. notoginseng were determined using high performance liquid chromatography. The contents and proportions of saponins were different among the four plant parts. Using the cell counting method, the antiproliferative effects were evaluated and the results indicated all four extracts, at 0.05-1.0 mg/mL, showed concentration-related antiproliferative effects on the cancer cells. The flower extract had stronger effects compared with the other three extracts; at 1.0 mg/mL, it inhibited the cell growth by 93.1% (p < 0.01). The antiproliferative effects of major saponins in notoginseng, notoginsenoside R1, ginsenosides Rb1, Rb3 and Rg1, were also evaluated, and the observed effects of major constituents support the pharmacological activities of extracts. The effects of notoginseng extracts on cell cycle and apoptosis of SW480 cells were determined using flow cytometry. Notoginseng extract can arrest the cells in S and G2/M phases. Remarkably apoptosis induction activities of notoginseng extracts were observed with the flower extract possessing the most potent effect, supporting the antiproliferative effect.
Authors:
Chong-Zhi Wang; Jing-Tian Xie; Anna Fishbein; Han H Aung; Hui He; Sangeeta R Mehendale; Tong-Chuan He; Wei Du; Chun-Su Yuan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  23     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-29     Completed Date:  2009-02-11     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  6-13     Citation Subset:  IM    
Copyright Information:
Copyright 2008 John Wiley & Sons, Ltd.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis / drug effects
Cell Cycle / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects*
Chromatography, High Pressure Liquid
Drugs, Chinese Herbal / pharmacology
Flow Cytometry
Flowers / chemistry
Fruit / chemistry
Ginsenosides / pharmacology*
Humans
Panax notoginseng / chemistry*
Plant Roots / chemistry
Rhizome / chemistry
Grant Support
ID/Acronym/Agency:
AT003255/AT/NCCAM NIH HHS; AT004418/AT/NCCAM NIH HHS; CA106569/CA/NCI NIH HHS; P01 AT004418/AT/NCCAM NIH HHS; P01 AT004418-01A1/AT/NCCAM NIH HHS; R21 AT002445/AT/NCCAM NIH HHS; R21 AT002445-02/AT/NCCAM NIH HHS; R21 AT003255/AT/NCCAM NIH HHS; R21 AT003255-02/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Drugs, Chinese Herbal; 0/Ginsenosides; 0/Panax notoginseng extract
Comments/Corrections

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