| Antiproliferative effect of retinoic acid in 1% sodium hyaluronate in an animal model of PVR. | |
| | |
MedLine Citation:
|
PMID: 9222089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To determine the antiproliferative activity in intravitreous retinoic acid (RA) dispersed in 1% sodium hyaluronate (HA). METHODS: Six groups of pigmented rabbits underwent gas-compression vitrectomy. Four days later, gas/HA or gas/balanced salt solution (BSS) exchange (1.0 m1) was performed in all rabbits. Groups A (n = 10) and B (n = 5) received intravitreous RA dissolved in 0.01 m1 of ethanol and dispersed in 1% HA (10 and 15 micrograms RA/m1, respectively). Group C (n = 10) received intravitreous RA dissolved in ethanol and dispersed in BSS (10 micrograms RA/m1). Groups D (n = 5) and F (n = 4) received 1 m1 of HA with ethanol; group E (n = 5) received 1 m1 of HA without ethanol. All groups except group F also received homologous fibroblasts and autologous, platelet-rich plasma intravitreously. The eyes were examined ophthalmoscopically for 1 month. Proliferative vitreoretinopathy (PVR) findings were graded according to the classification of Fastenberg et al. all group F eyes also were examined by light and electron microscopy. RESULTS: RA in HA lessened PVR progression within 1 month when compared with HA injection controls and within 2 weeks when compared with the RA in BSS treatment group (both, p < 0.05). NO specific change attributable to ethanol was observed histopathologically. CONCLUSION: RA dissolved in ethanol and dispersed in HA could be useful to treat PVR when silicone oil is unnecessary. |
| | |
Authors:
|
M Takahashi; M F Refojo; M Nakagawa; A Veloso; F L Leong |
Related Documents
:
|
21178669 - Preoperative cerebral oxygen saturation and clinical outcomes in cardiac surgery. 23287889 - Association of clopidogrel pretreatment with mortality, cardiovascular events, and majo... 23434769 - Telephone contact to improve adherence to dual antiplatelet therapy after drug-eluting ... 18238789 - Adalimumab in juvenile idiopathic arthritis-associated chronic anterior uveitis. 15115709 - The german etanercept registry for treatment of juvenile idiopathic arthritis. 19787419 - Prediction of das28-crp remission in patients with rheumatoid arthritis treated with ta... 15519919 - Vagus nerve stimulation therapy: 5-year or greater outcome at a university-based epilep... 21352989 - Topical application of a biodegradable disc with amiodarone for atrial fibrillation. 18057289 - Metallic stent placement in patients with recurrent cancer after gastrojejunostomy. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Current eye research Volume: 16 ISSN: 0271-3683 ISO Abbreviation: Curr. Eye Res. Publication Date: 1997 Jul |
Date Detail:
|
Created Date: 1997-09-02 Completed Date: 1997-09-02 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 8104312 Medline TA: Curr Eye Res Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 703-9 Citation Subset: IM |
Affiliation:
|
Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Transfusion Cell Division / drug effects Disease Models, Animal Ethanol Female Fibroblasts / transplantation Hyaluronic Acid Male Osmolar Concentration Plasma Platelet Transfusion Rabbits Sodium Chloride Solutions Tretinoin / administration & dosage*, therapeutic use Vitreoretinopathy, Proliferative / drug therapy*, therapy |
| Grant Support | |
ID/Acronym/Agency:
|
EY-00327/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Solutions; 302-79-4/Tretinoin; 64-17-5/Ethanol; 7647-14-5/Sodium Chloride; 9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lysophosphatidic acid stimulates proliferation of human retinal pigment epithelial cells.
Next Document: A low conductance chloride channel in the basolateral membranes of the non-pigmented ciliary epithel...