Document Detail


Antiproliferative effect of resveratrol in pancreatic cancer cells.
MedLine Citation:
PMID:  21031621     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate resveratrol, one of the food derived polyphenols that might be partially responsible for the beneficial effect on cancer, the in vitro antitumor activity of resveratrol against pancreatic cancer cell lines (PANC-1, BxPC-3 and AsPC-1) was examined, together with the mechanisms involved. The effects of resveratrol on the growth inhibition, apoptosis and cell cycle were assayed. The activity of caspases and the expression of Bcl-2, Bcl-xL, XIAP and Bax protein were detected. The results showed that resveratrol inhibited the proliferation of pancreatic cancer cells in a dose- and time-dependent manner. Resveratrol inhibited the cell growth of PANC-1, BxPC-3 and AsPC-1 cells with IC(50) values of 78.3 ± 9.6 μmol/L, 76.1 ± 7.8 μmol/L and 123.1 ± 6.5 μmol/L at 48 h, respectively. Incubation of pancreatic cancer cells with resveratrol resulted in cell apoptosis and cell cycle arrests. Resveratrol induced activation of caspases. Simultaneously, resveratrol regulated the expression of the antiapoptotic proteins Bcl-2, Bcl-xL and XIAP and the proapoptotic protein Bax. PANC-1 and BxPC-3 cells were more chemosensitive to resveratrol than AsPC-1 cells. In conclusion, resveratrol inhibited the proliferation of pancreatic cancer cells by inducing apoptotic cell death. There was different sensitivity to resveratrol in different pancreatic cancer cell lines.
Authors:
Jing Cui; Renhu Sun; Yangping Yu; Shanmiao Gou; Gang Zhao; Chunyou Wang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  24     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-01-18     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1637-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons, Ltd.
Affiliation:
Pancreatic Surgical Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / pharmacology*
Apoptosis / drug effects*
Caspases / metabolism
Cell Cycle / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects*
Cell Survival
Humans
Pancreatic Neoplasms / drug therapy*,  metabolism
Proto-Oncogene Proteins c-bcl-2 / metabolism
Stilbenes / pharmacology*
X-Linked Inhibitor of Apoptosis Protein / metabolism
bcl-2-Associated X Protein / metabolism
bcl-X Protein / metabolism
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Proto-Oncogene Proteins c-bcl-2; 0/Stilbenes; 0/X-Linked Inhibitor of Apoptosis Protein; 0/XIAP protein, human; 0/bcl-2-Associated X Protein; 0/bcl-X Protein; EC 3.4.22.-/Caspases; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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