Document Detail


Antiproliferative effect of α-mangostin on canine osteosarcoma cells.
MedLine Citation:
PMID:  22342127     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Osteosarcoma is the most frequently diagnosed primary bone tumor in dog. Since chemotherapeutics are quite limited due to high cost and severe toxicity, therefore, the ultimate goal is to discover cost-effective therapeutics with less toxicity. We have studied the effect of α-mangostin, a xanthone derivative isolated from pericarp of mangosteen (Garcinia mangostana Linn.) in canine osteosarcoma, D-17 cells. The results showed that α-mangostin induced antiproliferation with IC(50) at 15μg/ml. Hoechst 33342 nuclear staining and nucleosomal DNA-gel electrophoresis revealed that α-mangostin could induce nuclear condensation and fragmentation, typically seen in apoptosis. Cell cycle analysis demonstrated that α-mangostin induced sub-G1 peak. In addition, α-mangostin also induced membrane flipping of the phosphatidylserine and the loss of mitochondrial membrane potential in D-17 cells. In conclusion, α-mangostin, induced apoptotic cell death against canine osteosarcoma D-17 cells, could be a potential candidate for preventive and therapeutic application for bone cancer treatment in dogs.
Authors:
Aungkana Krajarng; Sirinun Nilwarankoon; Sunit Suksamrarn; Ramida Watanapokasin
Related Documents :
8660947 - Roles of xpg and xpf/ercc1 endonucleases in uv-induced immunostaining of pcna in fibrob...
22311427 - Engineered cells as biosensing systems in biomedical analysis.
20348017 - Differential participation of homologous recombination and nucleotide excision repair i...
19895277 - Influence of irradiation on metabolism and metastatic potential of b16-f10 melanoma cells.
20737197 - The impact of c-myc gene expression on gastric cancer cell.
2123147 - Effects of electric fields on cytoskeleton of corneal stromal fibroblasts.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-16
Journal Detail:
Title:  Research in veterinary science     Volume:  -     ISSN:  1532-2661     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401300     Medline TA:  Res Vet Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Use of a pressure plate to analyse the toe-heel load redistribution underneath a normal shoe and a s...
Next Document:  Patient factors predict periprosthetic fractures after revision total hip arthroplasty.