| Antiproliferative activity of anti-inflammatory drugs in two mammalian cell culture lines. | |
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MedLine Citation:
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PMID: 196069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The nonsteroid anti-inflammatory drugs inhibited cell proliferation when added to rat hepatoma and human fibroblast cultures. The inhibition was reversible; normal growth resumed when the cultures were washed free of drug. Protein and nucleic acid synthesis, as measured by isotope incorporation was also reduced, although this reduction was probably a reflection of the decrease in cell numbers. An exception was that, in low concentration, the salicylate drugs, salicylamide, salicylic acid and aspirin, stimulated protein and nucleic acid synthesis, but in high concentrations (greater than 1 mM) they inhibited culture growth as well as protein and nucleic acid synthesis. Pharmacologically inactive derivatives, such as m-hydroxybenzoic acid and gentisic acid, were not inhibitory in concentrations up to 5 mM. The order of potency in inhibiting culture growth, meclofenamate greater than indomethacin greater than salicylamide greater than phenylbutazone greater than phenacetin greater than aspirin = salicylic acid, was similar to that reported for their anti-inflammator activity and their ability to inhibit prostaglandin synthesis. The antiproliferative activity of these drugs may, in part, account for their anti-inflammatory and toxic actions in vivo. |
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Authors:
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V Hial; M C De Mello; Z Horakova; M A Beaven |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: The Journal of pharmacology and experimental therapeutics Volume: 202 ISSN: 0022-3565 ISO Abbreviation: J. Pharmacol. Exp. Ther. Publication Date: 1977 Aug |
Date Detail:
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Created Date: 1977-09-22 Completed Date: 1977-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376362 Medline TA: J Pharmacol Exp Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 446-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents / pharmacology* Carcinoma, Hepatocellular / metabolism Cell Division / drug effects* Cell Line Cyclooxygenase Inhibitors DNA / biosynthesis Dose-Response Relationship, Drug Fibroblasts / cytology, drug effects, metabolism Leucine / metabolism Liver Neoplasms / metabolism Protein Biosynthesis RNA / biosynthesis Rats Thymidine / metabolism Time Factors Uridine / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Cyclooxygenase Inhibitors; 50-89-5/Thymidine; 58-96-8/Uridine; 61-90-5/Leucine; 63231-63-0/RNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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