Document Detail


Antiproliferative activity of anti-inflammatory drugs in two mammalian cell culture lines.
MedLine Citation:
PMID:  196069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nonsteroid anti-inflammatory drugs inhibited cell proliferation when added to rat hepatoma and human fibroblast cultures. The inhibition was reversible; normal growth resumed when the cultures were washed free of drug. Protein and nucleic acid synthesis, as measured by isotope incorporation was also reduced, although this reduction was probably a reflection of the decrease in cell numbers. An exception was that, in low concentration, the salicylate drugs, salicylamide, salicylic acid and aspirin, stimulated protein and nucleic acid synthesis, but in high concentrations (greater than 1 mM) they inhibited culture growth as well as protein and nucleic acid synthesis. Pharmacologically inactive derivatives, such as m-hydroxybenzoic acid and gentisic acid, were not inhibitory in concentrations up to 5 mM. The order of potency in inhibiting culture growth, meclofenamate greater than indomethacin greater than salicylamide greater than phenylbutazone greater than phenacetin greater than aspirin = salicylic acid, was similar to that reported for their anti-inflammator activity and their ability to inhibit prostaglandin synthesis. The antiproliferative activity of these drugs may, in part, account for their anti-inflammatory and toxic actions in vivo.
Authors:
V Hial; M C De Mello; Z Horakova; M A Beaven
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  The Journal of pharmacology and experimental therapeutics     Volume:  202     ISSN:  0022-3565     ISO Abbreviation:  J. Pharmacol. Exp. Ther.     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-09-22     Completed Date:  1977-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376362     Medline TA:  J Pharmacol Exp Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  446-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / pharmacology*
Carcinoma, Hepatocellular / metabolism
Cell Division / drug effects*
Cell Line
Cyclooxygenase Inhibitors
DNA / biosynthesis
Dose-Response Relationship, Drug
Fibroblasts / cytology,  drug effects,  metabolism
Leucine / metabolism
Liver Neoplasms / metabolism
Protein Biosynthesis
RNA / biosynthesis
Rats
Thymidine / metabolism
Time Factors
Uridine / metabolism
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Cyclooxygenase Inhibitors; 50-89-5/Thymidine; 58-96-8/Uridine; 61-90-5/Leucine; 63231-63-0/RNA; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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