| Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part II. | |
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MedLine Citation:
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PMID: 19170144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antiproliferative activities of aqueous and organic extracts prepared from 26 Hungarian species of the tribes Cynereae and Lactuceae (Asteraceae) were tested in vitro against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells by using the MTT assay. Of the tested 200 extracts of different plant parts obtained with n-hexane, chloroform, 50% methanol and water, 16 extracts displayed noteworthy cell growth inhibitory activity (>50% inhibition at a concentration of 10 microg/mL). The IC50 values of these extracts were determined, and their direct cytotoxic effects were measured. High differences between the antiproliferative and cytotoxic activities, demonstrating a real cell proliferation inhibitory activity rather than direct killing effects, were found for some Centaurea, Cirsium, Cichorium, Lactuca, Onopordum and Scorsonera extracts. |
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Authors:
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Boglárka Csupor-Löffler; Zsuzsanna Hajdú; Borbála Réthy; István Zupkó; Imre Máthé; Tamás Rédei; George Falkay; Judit Hohmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 23 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-03 Completed Date: 2009-09-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 1109-15 Citation Subset: IM |
Copyright Information:
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Copyright 2009 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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pharmacology* Asteraceae / chemistry* Cell Line, Tumor Cell Proliferation / drug effects* Humans Plant Extracts / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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