| Antiproliferative effect and ultrastructural alterations induced by psilostachyin on Trypanosoma cruzi. | |
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MedLine Citation:
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PMID: 20110908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of psilostachyin, a natural sesquiterpene lactone, on the growth and viability of cultured epimastigotes of Trypanosoma cruzi (Tulahuen) is reported. The antiproliferative effect was evaluated by counting the parasites in a Neubauer chamber and measuring their viability by using the dye exclusion technique. The effect on parasite growth was irreversible at concentrations higher than 1.0 microg/mL and the addition of glutathione only partially blocked the effect of the compound. Moreover, we have studied the effects of this natural compound on parasite ultrastructure by transmission electron microscopy. Interestingly, psilostachyin induced ultrastructural alterations on the parasites at a concentration of 0.5 microg/mL, with important mitochondrial swelling and deformity of the kinetoplast. |
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Authors:
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Valeria Sülsen; Patricia Barrera; Liliana Muschietti; Virginia Martino; Miguel Sosa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-25 |
Journal Detail:
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Title: Molecules (Basel, Switzerland) Volume: 15 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-29 Completed Date: 2010-04-02 Revised Date: 2010-12-15 |
Medline Journal Info:
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Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
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Languages: eng Pagination: 545-53 Citation Subset: IM |
Affiliation:
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Cátedra de Farmacognosia, Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, IQUIMEFA (UBA-CONICET), Junín 956 (1113), CABA, Argentina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Assay Cell Death / drug effects Cell Proliferation / drug effects Cell Survival / drug effects Glutathione / pharmacology Mice Mice, Inbred BALB C Parasites / cytology, drug effects, growth & development, ultrastructure Sesquiterpenes / pharmacology* Trypanosoma cruzi / cytology*, drug effects, growth & development, ultrastructure* |
| Chemical | |
Reg. No./Substance:
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0/Sesquiterpenes; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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