| Antiproliferative activity of Greek propolis. | |
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MedLine Citation:
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PMID: 20132046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The butanolic extract and the isolated chemical constituents, mainly diterpenes and flavonoids, from Greek propolis have been tested for their cytostatic activities against human malignant and normal cell strains. The extract and the diterpenes were found to be the most active against HT-29 human colon adenocarcinoma cells, without affecting normal human cells. Manool, a diterpene isolated for the first time from Greek propolis, was the most active compound, arresting the cancer cells at the G(2)/M phase of the cell cycle. |
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Authors:
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Harris Pratsinis; Dimitris Kletsas; Eleni Melliou; Ioanna Chinou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of medicinal food Volume: 13 ISSN: 1557-7600 ISO Abbreviation: J Med Food Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
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Languages: eng Pagination: 286-90 Citation Subset: IM |
Affiliation:
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Laboratory of Cell Proliferation & Ageing, Institute of Biology, NCSR Demokritos, University of Athens, Athens, Greece. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy* Apitherapy* Cell Line, Tumor Cell Proliferation / drug effects* Colonic Neoplasms / drug therapy* Cytostatic Agents / isolation & purification, pharmacology*, therapeutic use Diterpenes / isolation & purification, pharmacology, therapeutic use* Flavonoids / isolation & purification, pharmacology, therapeutic use G2 Phase / drug effects Greece Humans Propolis / chemistry, pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Cytostatic Agents; 0/Diterpenes; 0/Flavonoids; 0/manool; 9009-62-5/Propolis |
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