Document Detail

Antiproliferative activity of Greek propolis.
MedLine Citation:
PMID:  20132046     Owner:  NLM     Status:  MEDLINE    
The butanolic extract and the isolated chemical constituents, mainly diterpenes and flavonoids, from Greek propolis have been tested for their cytostatic activities against human malignant and normal cell strains. The extract and the diterpenes were found to be the most active against HT-29 human colon adenocarcinoma cells, without affecting normal human cells. Manool, a diterpene isolated for the first time from Greek propolis, was the most active compound, arresting the cancer cells at the G(2)/M phase of the cell cycle.
Harris Pratsinis; Dimitris Kletsas; Eleni Melliou; Ioanna Chinou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medicinal food     Volume:  13     ISSN:  1557-7600     ISO Abbreviation:  J Med Food     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  286-90     Citation Subset:  IM    
Laboratory of Cell Proliferation & Ageing, Institute of Biology, NCSR Demokritos, University of Athens, Athens, Greece.
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MeSH Terms
Adenocarcinoma / drug therapy*
Cell Line, Tumor
Cell Proliferation / drug effects*
Colonic Neoplasms / drug therapy*
Cytostatic Agents / isolation & purification,  pharmacology*,  therapeutic use
Diterpenes / isolation & purification,  pharmacology,  therapeutic use*
Flavonoids / isolation & purification,  pharmacology,  therapeutic use
G2 Phase / drug effects
Propolis / chemistry,  pharmacology*,  therapeutic use
Reg. No./Substance:
0/Cytostatic Agents; 0/Diterpenes; 0/Flavonoids; 0/manool; 9009-62-5/Propolis

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