| Antiproliferative Activity and Apoptosis Induction of Eucalyptus Citriodora Resin and Its Major Bioactive Compound in Melanoma B16F10 Cells. | |
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MedLine Citation:
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PMID: 22838509 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Antiproliferative activity and apoptosis induction of ethyl acetate of Eucalyptus citriodora resin (EAEER) and its major bioactive compound in melanoma B16F10 cells were investigated. 6-[1-(p-hydroxy-phenyl)ethyl]-7-O-methyl aromadendrin (HEMA), a flavanol derivative, was isolated from EAEER and identified on the basis of its mass and NMR spectra. The results from MTT assay showed high antiproliferative effects of EAEER and HEMA on B16-F10 cells. Moreover, EAEER- and HEMA-induced cell apoptosis was association with the decrease in the mitochondrial transmembrane potentials (m), increase in Bax/Bcl-2 ratio, and activation of caspase-3. Cells treated with EAEER and HEMA generated intracellular reactive oxygen species (ROS) and nitric oxide (NO), indicating that ROS and RNS play important roles in the induction of apoptosis in B16-F10 cells. Taken together, EAEER and its major bioactive compound, HEMA, inhibited the proliferation of B16F10 cells via apoptosis and may be a potential antimelanoma agent. |
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Authors:
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Pin-Der Duh; Zong-Tsi Chen; Shwu-Woan Lee; Tsuey-Pin Lin; Ya-Ting Wang; Wen-Jye Yen; Ling-Feng Kuo; Heuy-Ling Chu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-27 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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