Document Detail

Antiplatelet therapy to prevent cardiovascular events and mortality in patients with intermittent claudication.
MedLine Citation:
PMID:  23462789     Owner:  NLM     Status:  MEDLINE    
CLINICAL QUESTION: Do antiplatelet therapies reduce risk of all-cause mortality, cardiovascular disease (CVD) mortality, and cardiovascular events in patients with intermittent claudication? Which antiplatelet is most strongly associated with a reduced risk of all-cause and CVD mortality?
BOTTOM LINE: In patients with intermittent claudication, antiplatelet therapies are associated with lower all-cause and CVD mortality compared with placebo. Compared with all antiplatelet therapies, the strongest evidence exists for thienopyridines, such as clopidogrel.
Peng Foo Wong; Lee-Yee Chong; Gerard Stansby
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  JAMA     Volume:  309     ISSN:  1538-3598     ISO Abbreviation:  JAMA     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-06     Completed Date:  2013-03-08     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  United States    
Other Details:
Languages:  eng     Pagination:  926-7     Citation Subset:  AIM; IM    
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MeSH Terms
Cardiovascular Diseases / mortality*,  prevention & control*
Cause of Death
Evidence-Based Medicine
Intermittent Claudication / complications*,  drug therapy
Platelet Aggregation Inhibitors / therapeutic use*
Practice Guidelines as Topic
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Platelet Aggregation Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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