| Antiplatelet therapy for stroke prevention in atrial fibrillation. | |
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MedLine Citation:
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PMID: 20222295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Warfarin has been the cornerstone therapy for stroke prevention in non-valvular atrial fibrillation (NVAF), particularly in patients at high risk of ischemic stroke or thromboembolism. Warfarin use in NVAF results in a 64% relative reduction in the incidence of ischemic stroke and several trials have demonstrated warfarin to be superior to aspirin alone (relative risk reduction-22%). However, anticoagulation with warfarin is associated with increased bleeding, especially in the elderly population. Anticoagaulation with warfarin requires close monitoring of the international standardized ratio (INR), which can be inconvenient to patients. Additionally, large numbers of patients on coumadin have a subtherapeutic INR level, which increases the risk of thromboembolic episodes. In part due to the above mentioned reasons, anticoagulation with warfarin is underutilized for stroke prevention. |
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Authors:
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Nadish Garg; Arun Kumar; Greg C Flaker |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Missouri medicine Volume: 107 ISSN: 0026-6620 ISO Abbreviation: Mo Med Publication Date: 2010 Jan-Feb |
Date Detail:
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Created Date: 2010-03-12 Completed Date: 2010-05-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0400744 Medline TA: Mo Med Country: United States |
Other Details:
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Languages: eng Pagination: 44-7 Citation Subset: IM |
Affiliation:
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University of Missouri Hospital and Clinics, Division of Cardiovascular Medicine, USA. gargn@health.missouri.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atrial Fibrillation
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complications*,
drug therapy* Drug Therapy, Combination Humans Platelet Aggregation Inhibitors / therapeutic use* Randomized Controlled Trials as Topic Stroke / etiology*, prevention & control* Warfarin / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 81-81-2/Warfarin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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