Document Detail

Antiplatelet therapy for stroke prevention in atrial fibrillation.
MedLine Citation:
PMID:  20222295     Owner:  NLM     Status:  MEDLINE    
Warfarin has been the cornerstone therapy for stroke prevention in non-valvular atrial fibrillation (NVAF), particularly in patients at high risk of ischemic stroke or thromboembolism. Warfarin use in NVAF results in a 64% relative reduction in the incidence of ischemic stroke and several trials have demonstrated warfarin to be superior to aspirin alone (relative risk reduction-22%). However, anticoagulation with warfarin is associated with increased bleeding, especially in the elderly population. Anticoagaulation with warfarin requires close monitoring of the international standardized ratio (INR), which can be inconvenient to patients. Additionally, large numbers of patients on coumadin have a subtherapeutic INR level, which increases the risk of thromboembolic episodes. In part due to the above mentioned reasons, anticoagulation with warfarin is underutilized for stroke prevention.
Nadish Garg; Arun Kumar; Greg C Flaker
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Missouri medicine     Volume:  107     ISSN:  0026-6620     ISO Abbreviation:  Mo Med     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-03-12     Completed Date:  2010-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400744     Medline TA:  Mo Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-7     Citation Subset:  IM    
University of Missouri Hospital and Clinics, Division of Cardiovascular Medicine, USA.
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MeSH Terms
Atrial Fibrillation / complications*,  drug therapy*
Drug Therapy, Combination
Platelet Aggregation Inhibitors / therapeutic use*
Randomized Controlled Trials as Topic
Stroke / etiology*,  prevention & control*
Warfarin / therapeutic use*
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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