Document Detail


Antiplatelet glycoprotein autoantibodies in patients with autoimmune diseases with and without thrombocytopenia.
MedLine Citation:
PMID:  8946279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The presence and specificity of antiplatelet autoantibodies in 32 patients with primary and 18 patients with secondary autoimmune thrombocytopenic purpura (AITP), as well as 11 non-thrombocytopenic patients with systemic autoimmune diseases, were studied. By means of the direct and indirect monoclonal antibody immobilization of platelet antigen (MAIPA) assay, antiplatelet autoantibodies were detected using monoclonal antibodies specific for platelet glycoproteins (GPs) Ib, IIb/IIIa, Ia/IIa, and IV. Serum antiplatelet autoantibodies were found in 18 of 32 primary AITP patients (56%), 6 of 18 secondary AITP patients (33%), and 5 of 11 nonthrombocytopenic patients (45%). Platelet-associated autoantibodies were detected in five of eight patients with primary (62%) and in four of eight patients with secondary AITP (50%) and in two of four patients without thrombocytopenia (50%). Multiple antibody reactivity, mainly against GPs IIb/IIIa and Ib and, in a few patients, against Ia/IIa, was found. Using MAIPA, platelet xylene eluates from 20 patients were also studied. Antiplatelet elutable autoantibodies were related to thrombocytopenia; autoantibodies against membrane GPs Ib and IIb/IIIa were demonstrable in 84 and 63% of eluates from patients with primary and secondary AITP, respectively, but not in eluates from nonthrombocytopenic patients. The presence of antiplatelet antibodies thus appears to be a common feature of many autoimmune diseases apart from the thrombocytopenia, but the (primary or secondary) etiology of the immune thrombocytopenia cannot be differentiated on the grounds of their specificity.
Authors:
I Cordiano; F Salvan; M L Randi; M A Ruffatti; A Steffan; A Girolami; F Fabris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical immunology     Volume:  16     ISSN:  0271-9142     ISO Abbreviation:  J. Clin. Immunol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-02-19     Completed Date:  1997-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102137     Medline TA:  J Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  340-7     Citation Subset:  IM    
Affiliation:
Institute of Medical Semeiotics, University of Padua Medical School, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Monoclonal
Autoantibodies / analysis*
Autoantigens / immunology
Autoimmune Diseases / complications,  immunology*
Blood Platelets / immunology*
Female
Fluorescent Antibody Technique
Humans
Male
Middle Aged
Platelet Membrane Glycoproteins / immunology*
Purpura, Thrombocytopenic, Idiopathic / complications,  immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Autoantibodies; 0/Autoantigens; 0/Platelet Membrane Glycoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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