Document Detail

Antiplatelet drug use in patients with non-ST-segment elevation acute coronary syndromes.
MedLine Citation:
PMID:  23391671     Owner:  NLM     Status:  In-Data-Review    
Patients with unstable angina pectoris/non-ST-segment elevation myocardial infarction have an acute coronary syndrome. These patients should be treated with dual antiplatelet therapy with the use of aspirin plus either clopidogrel, prasugrel, or ticagrelor, depending on the clinical circumstances. Prasugrel must not be used in patients with a history of stroke or transient ischemic attack. If ticagrelor is used, the dose of aspirin must not be > 100 mg daily. Platelet glycoprotein IIb/IIIa inhibitors should not be used as part of triple antiplatelet therapy if there is an increased risk for bleeding or in non-high-risk patients, such as those with a normal baseline cardiac troponin level, those without diabetes, and those aged ≥ 75 years for whom potential benefit may be significantly offset by the potential risk for bleeding. Clinical trial data do not support the use of intravenous cangrelor or oral vorapaxar in the treatment of patients with acute coronary syndromes.
Wilbert S Aronow
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medicine     Volume:  125     ISSN:  1941-9260     ISO Abbreviation:  Postgrad Med     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-02-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401147     Medline TA:  Postgrad Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  51-8     Citation Subset:  AIM; IM    
Cardiology Division, Department of Medicine, New York Medical College, Valhalla, NY.
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