Document Detail

Antiplatelet agents for secondary prevention of ischemic stroke.
MedLine Citation:
PMID:  11675854     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review and summarize the efficacy, mechanisms of action, and cost of the options available when choosing antiplatelet agents for secondary stroke prevention. DATA SOURCES: This article is based on a review of the literature found with MEDLINE, CINAHL, and Cochrane Reviews (1980-June 2000) and abstracts from relevant international scientific meetings. We searched for the terms aspirin, ticlopidine, dipyridamole, antiplatelet, and clopidogrel. STUDY SELECTION: English-language articles, both reviews and original studies, were evaluated, and all information considered relevant was included in this review. In addition, guidelines from the American Heart Association are included. DATA SYNTHESIS: Aspirin is a relatively inexpensive and effective agent for secondary stroke prevention, and lower doses of aspirin appear as effective as higher doses. Ticlopidine has been used alone or in combination with aspirin, but serious adverse effects have limited its use. Clopidogrel has emerged as a safe and effective alternative to ticlopidine and lacks some of the serious adverse effects associated with ticlopicine, but is not superior to aspirin in secondary stroke prevention. Unlike previous studies, one recent trial showed that dipyridamole in combination with aspirin is superior to aspirin alone. CONCLUSIONS: Antiplatelet therapy is a key component of secondary prevention strategies in ischemic stroke. While aspirin has been the cornerstone in the management of stroke, other classes of antiplatelet drugs present new opportunities to optimize antiplatelet therapy.
A Majid; N Delanty; J Kantor
Related Documents :
3595474 - The evolution of non-steroidal anti-inflammatory drugs and their mechanisms of action.
12637254 - Gastritis increases resistance to aspirin-induced mucosal injury via cox-2-mediated lip...
6348804 - Low-dose aspirin (asa) renders human platelets more vulnerable to inhibition of aggrega...
11192944 - Antiplatelet action of losartan involves txa2 receptor antagonism but not txa2 synthase...
18315514 - Synergistic action of starch and honey against pseudomonas aeruginosa in correlation wi...
15261164 - 2,4,5-t and 2,4,5-tcp induce oxidative damage in human erythrocytes: the role of glutat...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  35     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-24     Completed Date:  2002-03-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1241-7     Citation Subset:  IM    
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aspirin / administration & dosage,  adverse effects,  therapeutic use
Clinical Trials as Topic
Cost-Benefit Analysis
Dipyridamole / administration & dosage,  adverse effects,  therapeutic use
Myocardial Ischemia / prevention & control*
Platelet Aggregation Inhibitors / therapeutic use*
Stroke / prevention & control*
Ticlopidine / adverse effects,  analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 55142-85-3/Ticlopidine; 58-32-2/Dipyridamole; 90055-48-4/clopidogrel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Tenecteplase for treatment of acute myocardial infarction.
Next Document:  Amiodarone in the new AHA guidelines for ventricular tachyarrhythmias.