| Antiplatelet and anticoagulant therapies in acute coronary syndromes. | |
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MedLine Citation:
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PMID: 20033270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The combination of aspirin and clopidogrel is the mainstay antiplatelet therapy for acute coronary syndromes (ACS). However, the dosing of aspirin, the dosing of clopidogrel, the timing of clopidogrel initiation as well as the duration of clopidogrel therapy remain controversial matters. Clopidogrel resistance is an emerging concept with potential clinical implications. In the era of clopidogrel and bivalirudin, the role of glycoprotein IIb/IIIa antagonists is being challenged, yet they are still indicated in a select high-risk population. Concerning anticoagulant use in ACS, newer agents, bivalirudin and fondaparinux, have improved outcomes in comparison to heparin in patients managed with an invasive or conservative strategy, respectively. Combining multiple antiplatelet agents and an anticoagulant is the standard of care for ACS. |
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Authors:
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Elias B Hanna; David Luke Glancy; Jorge F Saucedo |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Volume: 24 ISSN: 1573-7241 ISO Abbreviation: Cardiovasc Drugs Ther Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-04-15 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8712220 Medline TA: Cardiovasc Drugs Ther Country: United States |
Other Details:
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Languages: eng Pagination: 61-70 Citation Subset: IM |
Affiliation:
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Cardiology Department, Oklahoma University, Oklahoma City, 73190, USA. elias-hanna@ouhsc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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drug therapy* Anticoagulants / administration & dosage, adverse effects, pharmacology, therapeutic use* Drug Therapy, Combination / methods, trends Humans Platelet Aggregation Inhibitors / administration & dosage, adverse effects, pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Platelet Aggregation Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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