Document Detail


Antiplasmodial and antitrypanosomal activity of bicyclic amides and esters of dialkylamino acids.
MedLine Citation:
PMID:  19395265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several bicyclic amides and esters of dialkylamino acids were prepared. Their activities against a multiresistant strain of Plasmodium falciparum and against Trypanosoma brucei rhodesiense (STIB 900) were examined. Structure-activity relationships were discussed. Particularly the ester compounds showed good antiplasmodial and antitrypanosomal activity and a single compound was tested in vivo against Plasmodium berghei.
Authors:
Johanna Faist; Werner Seebacher; Christian Schlapper; Marcel Kaiser; Reto Brun; Robert Saf; Robert Weis
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Publication Detail:
Type:  Journal Article     Date:  2009-04-07
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  17     ISSN:  1464-3391     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-06     Completed Date:  2009-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  3595-603     Citation Subset:  IM    
Affiliation:
Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Universitätsplatz 1, A-8010 Graz, Austria.
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MeSH Terms
Descriptor/Qualifier:
Amides / chemical synthesis,  chemistry*
Amino Acids / chemistry*
Animals
Antimalarials / chemical synthesis,  chemistry,  toxicity*
Bicyclo Compounds / chemical synthesis,  chemistry,  toxicity*
Esters / chemical synthesis,  chemistry
Parasitic Sensitivity Tests
Plasmodium berghei / drug effects
Plasmodium falciparum / drug effects
Structure-Activity Relationship
Trypanocidal Agents / chemical synthesis,  chemistry,  toxicity*
Trypanosoma brucei rhodesiense / drug effects
Chemical
Reg. No./Substance:
0/Amides; 0/Amino Acids; 0/Antimalarials; 0/Bicyclo Compounds; 0/Esters; 0/Trypanocidal Agents

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