Document Detail


Antiphospohlipid syndrome in obstetrics.
MedLine Citation:
PMID:  22079775     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Antiphospholipid syndrome is characterised by a variety of clinical and immunological manifestations. The clinical hallmarks of this syndrome are thrombosis and poor obstetric outcomes, including miscarriages, fetal loss and severe pre-eclampsia. The main antiphospholipid antibodies include lupus anticoagulant, anticardiolipin and anti-β2-glycoprotein I. The combination of aspirin and heparin is considered the standard of care for women with antiphospholipid syndrome and embryo-fetal losses; however, aspirin in monotherapy may have a place in women with recurrent early miscarriage. A good benefit-risk ratio of low-molecular-weight heparin in pregnancy thrombosis treatment has been reported. Warfarin must be avoided if possible throughout the first trimester of pregnancy. Adequate pregnancy management of women with antiphospholipid syndrome should include co-ordinated medical-obstetrical care, a close follow-up protocol and a good neonatal unit. Close blood pressure control and early detection of proteinuria, together with Doppler studies of the utero-placental circulation should be included in the management protocol.
Authors:
Alvaro Danza; Guillermo Ruiz-Irastorza; Munther Khamashta
Related Documents :
14511965 - Glomerular endotheliosis in normal pregnancy and pre-eclampsia.
15491015 - Hypertension in pregnancy.
12566245 - Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast int...
12699805 - Magnetic resonance spectroscopy in pre-eclampsia: evidence of cerebral ischaemia.
16998815 - Risks of hyperthermia associated with hot tub or spa use by pregnant women.
1725365 - Comparison of endothelin-1 concentrations in normal and complicated pregnancies.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-10
Journal Detail:
Title:  Best practice & research. Clinical obstetrics & gynaecology     Volume:  -     ISSN:  1532-1932     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101121582     Medline TA:  Best Pract Res Clin Obstet Gynaecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Affiliation:
Autoimmune Diseases Research Unit, Department of Internal Medicine, Hospital Universitario Cruces, University of the Basque Country, Bizkaia, Spain; Clinical Department of Medicine, Hospital de Clinicas, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Undirected head movements of listeners with asymmetrical hearing impairment during a speech-in-noise...
Next Document:  Systematic engineering of 3D pluripotent stem cell niches to guide blood development.