| Antiphospholipid syndrome. | |
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MedLine Citation:
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PMID: 19732604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antiphospholipid syndrome (APS) is an autoimmune systemic disease that is diagnosed when there is vascular thrombosis and/or pregnancy morbidity occurring with persistently positive antiphospholipid antibodies (aPL) (lupus anticoagulant test, anticardiolipin antibodies, and/or anti-beta(2)-glycoprotein I antibodies). Although International APS Classification Criteria have been formulated to provide a uniform approach to APS research, aPL may cause a spectrum of clinical manifestations, some of which are not included in these criteria. The main aPL-related cardiac manifestations include valve abnormalities (vegetations and/or thickening), myocardial infarction (MI), intracardiac thrombi, and myocardial microthrombosis. In this article, we will review the definition, etiopathogenesis, clinical manifestations, diagnosis, and treatment of aPL-related clinical events with emphasis on cardiac manifestations. |
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Authors:
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Diane George; Doruk Erkan |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Progress in cardiovascular diseases Volume: 52 ISSN: 1873-1740 ISO Abbreviation: Prog Cardiovasc Dis Publication Date: 2009 Sep-Oct |
Date Detail:
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Created Date: 2009-09-07 Completed Date: 2009-09-18 Revised Date: 2013-05-02 |
Medline Journal Info:
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Nlm Unique ID: 0376442 Medline TA: Prog Cardiovasc Dis Country: United States |
Other Details:
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Languages: eng Pagination: 115-25 Citation Subset: AIM; IM |
Affiliation:
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Department of Rheumatology, Yale School of Medicine, New Haven, CT 06520, USA. dtg24@pantheon.yale.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Antiphospholipid
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immunology Antiphospholipid Syndrome* / complications, diagnosis, epidemiology, immunology, therapy Aspirin / administration & dosage Comorbidity Female Humans Lupus Coagulation Inhibitor / blood Myocardial Infarction / etiology, immunology Platelet Aggregation Inhibitors / administration & dosage Pregnancy Pregnancy Complications / immunology, prevention & control, therapy Pregnancy Outcome Thrombosis / epidemiology, immunology, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antiphospholipid; 0/Lupus Coagulation Inhibitor; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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