Document Detail

Antiphospholipid syndrome.
MedLine Citation:
PMID:  19732604     Owner:  NLM     Status:  MEDLINE    
The antiphospholipid syndrome (APS) is an autoimmune systemic disease that is diagnosed when there is vascular thrombosis and/or pregnancy morbidity occurring with persistently positive antiphospholipid antibodies (aPL) (lupus anticoagulant test, anticardiolipin antibodies, and/or anti-beta(2)-glycoprotein I antibodies). Although International APS Classification Criteria have been formulated to provide a uniform approach to APS research, aPL may cause a spectrum of clinical manifestations, some of which are not included in these criteria. The main aPL-related cardiac manifestations include valve abnormalities (vegetations and/or thickening), myocardial infarction (MI), intracardiac thrombi, and myocardial microthrombosis. In this article, we will review the definition, etiopathogenesis, clinical manifestations, diagnosis, and treatment of aPL-related clinical events with emphasis on cardiac manifestations.
Diane George; Doruk Erkan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in cardiovascular diseases     Volume:  52     ISSN:  1873-1740     ISO Abbreviation:  Prog Cardiovasc Dis     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2009-09-07     Completed Date:  2009-09-18     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  0376442     Medline TA:  Prog Cardiovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  115-25     Citation Subset:  AIM; IM    
Department of Rheumatology, Yale School of Medicine, New Haven, CT 06520, USA.
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MeSH Terms
Antibodies, Antiphospholipid / immunology
Antiphospholipid Syndrome* / complications,  diagnosis,  epidemiology,  immunology,  therapy
Aspirin / administration & dosage
Lupus Coagulation Inhibitor / blood
Myocardial Infarction / etiology,  immunology
Platelet Aggregation Inhibitors / administration & dosage
Pregnancy Complications / immunology,  prevention & control,  therapy
Pregnancy Outcome
Thrombosis / epidemiology,  immunology,  prevention & control
Reg. No./Substance:
0/Antibodies, Antiphospholipid; 0/Lupus Coagulation Inhibitor; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin

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