Document Detail

Antiphospholipid syndrome: a survey of clinical characters in ten cases.
MedLine Citation:
PMID:  12958725     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To gain further understanding of the antiphospholipid syndrome(APS). METHODS: Analysing clinical and laboratory data on ten cases of APS. RESULTS: Thrombocytopenia appeared in all cases. Venous thrombi of limbs appeared in five cases and neurological abnormalities in two cases. Renal impairments were found in three cases. One case manifested left renal venous thrombi and the other two cases thrombotic microangiopathy. Budd-Chiari syndrome was found in one case. One of the ten cases was catastrophic APS (CAPS) presented as acute diffuse swelling, cyanosis, pain, ischemia and necrosis in fingers and limbs, recurrent shock, ascites, hepatic and respiratory dysfunction. Anticoagulants and corticosteroids could be effective for dealing with APS. It was critical to treat catastrophic APS with anticoagulants or plasmapheresis as early as possible. CONCLUSIONS: APS shows variable manifestations for good prognosis, but catastrophic APS has fatal risk. The main treatment for APS is the use of anticoagulants and immunosuppressives.
Li-hua Chen; Ling-ling Jiang; You-ming Li; Qing-bi Peng
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Zhejiang University. Science     Volume:  4     ISSN:  1009-3095     ISO Abbreviation:  J. Zhejiang Univ. Sci.     Publication Date:    2003 Sep-Oct
Date Detail:
Created Date:  2003-09-05     Completed Date:  2004-06-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100954270     Medline TA:  J Zhejiang Univ Sci     Country:  China    
Other Details:
Languages:  eng     Pagination:  616-9     Citation Subset:  IM    
Department of Internal Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Anticoagulants / therapeutic use
Antiphospholipid Syndrome / diagnosis*,  drug therapy
Immunosuppressive Agents / therapeutic use
Kidney / pathology
Middle Aged
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Anticoagulants; 0/Immunosuppressive Agents

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