Document Detail

Antiphospholipid syndrome presenting as unilateral renal artery occlusion: case report and literature review.
MedLine Citation:
PMID:  19037608     Owner:  NLM     Status:  MEDLINE    
The objective of this study is to report a case of primary antiphospholipid syndrome (APS) presenting as complete renal artery occlusion, and to review the literature on the subject. We describe the clinical presentation, course and outcome of one patient who presented with resistant hypertension later found to be due to thrombosis and complete occlusion of the left renal artery. We review the medical literature registered in the Medline PubMed database from 1966 to 2004 using keywords: antiphospholipid, Hughes syndrome, kidney, renal, renal artery thrombosis. We describe one patient and analyzed ten well-documented cases of renal artery thrombosis due to APS. Most of the patients were women, at a mean age of 32 years. All but one case had primary APS. The presenting symptom was hypertension in ten cases. Most patients had both lupus anticoagulant and anticardiolipin antibodies. Arterial occlusion was left sided in 55%, right sided in 27% and bilateral in 18%. Renal artery thrombosis is an uncommon presentation of APS. This entity should be considered in the differential diagnosis of severe hypertension.
Doron Boltin; Victoria Boguslavski; Lior Sagi; Yoav Goor; Ori Elkayam
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2008-11-27
Journal Detail:
Title:  Rheumatology international     Volume:  29     ISSN:  1437-160X     ISO Abbreviation:  Rheumatol. Int.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-01     Completed Date:  2009-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206885     Medline TA:  Rheumatol Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  831-5     Citation Subset:  IM    
Department of Internal Medicine F, Tel Aviv Medical Center and the Sackler School of Medicine, Tel Aviv University, 6 Weizman street, 64239, Tel Aviv, Israel.
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MeSH Terms
Age Distribution
Anticoagulants / therapeutic use
Antihypertensive Agents / therapeutic use
Antiphospholipid Syndrome / complications*,  diagnosis*
Autoantibodies / blood
Blood Pressure / physiology
Functional Laterality / physiology
Hypertension, Renal / diagnosis*,  etiology*,  physiopathology
Kidney / blood supply,  pathology,  physiopathology
Middle Aged
Phospholipids / immunology,  metabolism
Renal Artery / pathology,  physiopathology
Renal Artery Obstruction / diagnosis*,  etiology*,  physiopathology
Sex Distribution
Tomography, X-Ray Computed
Treatment Outcome
Reg. No./Substance:
0/Anticoagulants; 0/Antihypertensive Agents; 0/Autoantibodies; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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