| Antiphospholipid antibody-mediated disruption of the annexin-V antithrombotic shield: a thrombogenic mechanism for the antiphospholipid syndrome. | |
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MedLine Citation:
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PMID: 10968894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanism(s) for thrombosis and pregnancy losses in the anti-phospholipid antibody syndrome have not yet been established. Annexin-V is an anionic phospholipid-binding protein with potent anticoagulant activity. The protein has been shown to be necessary for the maintenance of placental integrity and may play a thromboregulatory role at the maternal-fetal interface. There, it assembles over the apical surfaces of the placental villi and shields the underlying anionic phospholipids from availability for complexation with coagulation proteins. We have proposed that thrombosis and pregnancy loss in the antiphospholipid syndrome may be due to the disruption of the annexin-V shield by antiphospholipid (and co-factor) antibodies. The data accumulated from tissue immunohistochemistry, trophoblast and endothelial cell culture studies, coagulation studies using non-cellular phospholipids, and competition studies on artificial phospholipid bilayer are consistent with this hypothesis. |
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Authors:
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J H Rand |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of autoimmunity Volume: 15 ISSN: 0896-8411 ISO Abbreviation: J. Autoimmun. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2001-01-26 Completed Date: 2001-03-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8812164 Medline TA: J Autoimmun Country: England |
Other Details:
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Languages: eng Pagination: 107-11 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Academic Press. |
Affiliation:
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Division of Hematology, Department of Medicine, The Mount Sinai School of Medicine, New York, NY, USA. jacob.rand@mssm.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Habitual
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blood,
etiology,
immunology Animals Annexin A5 / blood, physiology* Antibodies, Antiphospholipid / physiology* Antiphospholipid Syndrome / blood, complications* Female Humans Pregnancy Thrombosis / etiology*, immunology, prevention & control* |
| Grant Support | |
ID/Acronym/Agency:
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HL-61331/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Annexin A5; 0/Antibodies, Antiphospholipid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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